Advances in Circular RNA and Its Applications

Zhao, Xian; Zhong, Yulong; Wang, Xudong; Shen, Jiuheng; An, Wenlin

doi:10.7150/ijms.71840

Cited by 73 publications

(51 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…circRNAs are a kind of covalently closed single-stranded lncRNAs generated by reverse splicing of mRNA precursors (pre-mRNAs), which means that the 5′ splice site is directly joined with a downstream 3′ splice site to be covalently bonded [ 44 , 68 , 69 , 70 , 71 , 72 ]. Notably, circRNAs can be hosted in coding genes whose levels are in turn regulated by those circRNAs.…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…Interestingly, circRNA expression is mostly tissue-specific due to the highly cell-type-specific manner of interaction with RBP [ 68 ]. Due to their special circular conformation, lacking 3′ poly(A) tail and 5′ cap structures, circRNAs are more resistant to degradation by exonucleases than linear sequences.…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…Due to their special circular conformation, lacking 3′ poly(A) tail and 5′ cap structures, circRNAs are more resistant to degradation by exonucleases than linear sequences. Consequently, they have a longer half-life suitable for measurement in biofluids [ 44 , 68 , 74 ].…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…This feature stems from their ability to present repeated MREs, acting as effective sponges of miRNAs, or even blocking their complementary sequences in the 3′UTR of the target mRNAs ( Figure 7 ) [ 40 , 47 , 63 , 68 , 74 ]. In addition to behaving as a miRNA sponge, circRNAs can bind proteins and so act as a scaffold to promote protein–protein interactions, or can sponge target proteins to modify their fate [ 40 , 47 , 65 , 68 , 74 ]. Two circRNAs widely expressed in the heart are heart-related circRNA (HRCR) and CDR1.…”

Section: Non-coding Rnasmentioning

confidence: 99%

See 3 more Smart Citations

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

et al. 2022

View full text Add to dashboard Cite

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy histologically characterized by the replacement of myocardium by fibrofatty infiltration, cardiomyocyte loss, and inflammation. ACM has been defined as a desmosomal disease because most of the mutations causing the disease are located in genes encoding desmosomal proteins. Interestingly, the instable structures of these intercellular junctions in this disease are closely related to a perturbed Wnt/β-catenin pathway. Imbalance in the Wnt/β-catenin signaling and also in the crosslinked Hippo pathway leads to the transcription of proadipogenic and profibrotic genes. Aiming to shed light on the mechanisms by which Wnt/β-catenin and Hippo pathways modulate the progression of the pathological ACM phenotype, the study of non-coding RNAs (ncRNAs) has emerged as a potential source of actionable targets. ncRNAs comprise a wide range of RNA species (short, large, linear, circular) which are able to finely tune gene expression and determine the final phenotype. Some share recognition sites, thus referred to as competing endogenous RNAs (ceRNAs), and ensure a coordinating action. Recent cancer research studies regarding the key role of ceRNAs in Wnt/β-catenin and Hippo pathways modulation pave the way to better understanding the molecular mechanisms underlying ACM.

show abstract

Section: Non-coding Rnasmentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

See 2 more Smart Citations

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As a kind of endogenous ncRNA, circRNA widely exists in various cells of various organisms, is abundantly expressed, and has high cell specificity, tissue specificity, and developmental stage specificity [ 30 , 31 ]. CircRNA is produced by the covalent attachment of spliceosome-mediated mRNA 3’ splice sites to 5’ splice sites [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Chi-Circ_0006511 Positively Regulates the Differentiation of Goat Intramuscular Adipocytes via Novel-miR-87/CD36 Axis

Zhang

Wang

et al. 2022

IJMS

View full text Add to dashboard Cite

Goats are an important livestock and goat meat is essential to local people. The intramuscular fat (IMF) content has a great influence on the quality of goat meat. The intramuscular preadipocytes differentiation is closely related to the IMF deposition; however, its potential regulatory mechanisms remain unclear. CircRNAs were revealed to be involved in multiple biological progressions. In this study, we took primary goat intramuscular preadipocyte (GIMPA) as the study model to verify the function and mechanism of chi-circ_0006511, which was abundant and up-regulated in mature adipocytes (GIMA). The results showed that the expression level of chi-circ_0006511 gradually increased in the early stage of GIMPA differentiation, and chi-circ_0006511 was confirmed to promote GIMPA lipid droplets aggregation and up-regulate the adipogenic differentiation determinants, further promoting GIMPA differentiation. Mechanistically, chi-circ_0006511 exerts its function by sponging novel-miR-87, thereby regulating the expression of CD36. The results from this study provided novel significant information to better understand the molecular regulatory mechanism of intramuscular preadipocytes differentiation, thereby providing a new reference for the intramuscular fat adipogenesis in goats.

show abstract

CircRNA and ferroptosis in human disease: Insights for new treatments

Liu,

Zhou,

Cao

2023

Anim Models and Exp Med

View full text Add to dashboard Cite

Circular RNA (circRNA), classified as a type of non‐coding RNA, has gained significant attention in the field of biology due to its distinctive ring structure and functional properties. Recent research has provided evidence that specific circRNAs have the ability to modulate disease progression through diverse mechanisms, one of which is by regulating cellular ferroptosis. Ferroptosis is a form of regulated cell death that is driven by iron dependency and lipid peroxidation, and extensive investigations have revealed a relationship between ferroptosis and disease development. In addition to evidence that both circRNAs and ferroptosis exert critical roles in disease progression, circRNAs have also been shown to actively mediate the process of ferroptosis. The relationship between circRNAs and ferroptosis therefore influences disease progression and offers novel targets for disease treatment. By directly or indirectly modulating the expression of circRNAs that regulate the expression of ferroptosis‐related proteins, it may be possible to impact disease progression by promoting or inhibiting ferroptosis. Current research indicates such approaches may hold significant value in a wide variety of common diseases across physiological systems. This review comprehensively summarizes the findings of recent studies investigating the roles of circRNAs in the regulation of ferroptosis in various diseases.

show abstract

Advances in Circular RNA and Its Applications

Cited by 73 publications

References 108 publications

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

Chi-Circ_0006511 Positively Regulates the Differentiation of Goat Intramuscular Adipocytes via Novel-miR-87/CD36 Axis

CircRNA and ferroptosis in human disease: Insights for new treatments

Contact Info

Product

Resources

About