Advances in chitosan-based nanoparticles for oncotherapy

Zhang, En-Hui; Xing, Ronge; Liu, Song; Qin, Yukun; Li, Kecheng; Li, Pengcheng

doi:10.1016/j.carbpol.2019.115004

Cited by 125 publications

(93 citation statements)

References 118 publications

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“…The particle sizes of aNP2 and bNP2 were the smallest, with PDIs lower than 0.3 indicating that there might be an optimal %DD and MW for nanoparticle formation. It is clear that the %DD, and MW of chitosan exerted combined effects on the chitosan nanoparticle characteristics [18].…”

Section: Particle Size Polydispersity Index (Pdi) and Zeta Potentialmentioning

confidence: 99%

“…Chitosan-based nanoparticles are commonly obtained by ionic gelation using the multivalent ion tripolyphosphate (TPP) [14][15][16] which possesses a large number of lone-pair electrons and high binding power with materials with empty orbitals [14]. Previous studies have demonstrated the effects of %DD, and MW of chitosan on the characteristics of the resulting nanoparticles [9,[17][18][19][20], such as particle size [17,19,20], zeta potential [17,19,20], and crystalline structure [19]. The crystalline structure of chitosan is strongly dependent on its deacetylation process, as well as its chitin polymorphic form [1,[21][22][23][24][25].…”

mentioning

confidence: 99%

“…The crystalline structure of chitosan is strongly dependent on its deacetylation process, as well as its chitin polymorphic form [1,[21][22][23][24][25]. Ionic cross-linked chitosan nanoparticles are fabricated through electrostatic interactions, in which the amino groups on the backbone interact with polyanionic cross-linking agents offering made-to-order chitosan nanoparticles by modifying the processing parameters, which subsequently influences their functional properties [18]. It is uncertain how differences in polymorphic structure affect the formation of ionic gels [5], which may lead to different antioxidant actions.…”

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confidence: 99%

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Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

2019

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α- and β-Chitosan nanoparticles were obtained from shrimp shell and squid pen chitosan with different set of deacetylation degree (%DD) and molecular weight (MW) combinations. After nanoparticle formation via ionic gelation with sodium tripolyphosphate (TPP), the % crystallinity index (%CI) of the α- and β-chitosan nanoparticles were reduced to approximately 33% and 43% of the initial %CI of the corresponding α- and β-chitosan raw samples, respectively. Both forms of chitosan and chitosan nanoparticles scavenged superoxide radicals in a dose-dependent manner. The %CI of α- and β-chitosan and chitosan nanoparticles was significantly negatively correlated with superoxide radical scavenging abilities over the range of concentration (0.5, 1, 2 and 3 mg/mL) studied. High %DD, and low MW β-chitosan exhibited the highest superoxide radical scavenging activity (p < 0.05). α- and β-Chitosan nanoparticles prepared from high %DD and low MW chitosan demonstrated the highest abilities to scavenge superoxide radicals at 2.0–3.0 mg/mL (p < 0.05), whereas α-chitosan nanoparticles, with the lowest %CI, and smallest particle size (p < 0.05), prepared from medium %DD, and medium MW chitosan showed the highest abilities to scavenge superoxide radicals at 0.5–1.0 mg/mL (p < 0.05). It could be concluded that α- and β-chitosan nanoparticles had superior superoxide radical scavenging abilities than raw chitosan samples.

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Section: Particle Size Polydispersity Index (Pdi) and Zeta Potentialmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

2019

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“…With the development of nanotechnology, chitosan derivatives have been prepared as nanomaterials, including nanoparticles, hydrogels, microspheres, and micelles. Chitosan derivatives can be used as targeted delivery vehicles for drugs, as well as adjuvants and delivery carriers for vaccines [14][15][16][17][18][19][20]. Therefore, chitosan derivatives and their nanomaterials can be widely used and expanded upon in terms of the fields of chitosan application [21,22].…”

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confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

586

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…As a large constituent of the polysaccharide family, chitosan (CS) bears excellent potential for the development of biointegrated electronic devices, in application to sensor skins, biomedical diagnosis and therapy, and brain-machine interfaces [12][13][14][15][16][17][18]. Its appealing properties consist of biocompatibility, biodegradatiblity, bioresorbability, natural abundance and light weight [19,20].…”

Section: Introductionmentioning

confidence: 99%

Biomemristic Behavior for Water-Soluble Chitosan Blended with Graphene Quantum Dot Nanocomposite

2020

Nanomaterials

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Bionanocomposite has promising biomemristic behaviors for data storage inspired by a natural biomaterial matrix. Carboxylated chitosan (CCS), a water-soluble derivative of chitosan avoiding the acidic salt removal, has better biodegradability and bioactivity, and is able to absorb graphene quantum dots (GQDs) employed as charge-trapping centers. In this investigation, biomemristic devices based on water-soluble CCS:GQDs nanocomposites were successfully achieved with the aid of the spin-casting method. The promotion of binary biomemristic behaviors for Ni/CCS:GQDs/indium-tin-oxide (ITO) was evaluated for distinct weight ratios of the chemical components. Fourier transform infrared spectroscopy, Raman spectroscopy (temperature dependence), thermogravimetric analyses and scanning electron microscopy were performed to assess the nature of the CCS:GQDs nanocomposites. The fitting curves on the experimental data further confirmed that the conduction mechanism might be attributed to charge trapping–detrapping in the CCS:GQDs nanocomposite film. Advances in water-soluble CCS-based electronic devices would open new avenues in the biocompatibility and integration of high-performance biointegrated electronics.

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Advances in chitosan-based nanoparticles for oncotherapy

Cited by 125 publications

References 118 publications

Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

Chitosan Derivatives and Their Application in Biomedicine

Biomemristic Behavior for Water-Soluble Chitosan Blended with Graphene Quantum Dot Nanocomposite

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