Advances in chemical studies on low-molecular weight metabolites of marine fungi

Biabani, M. A. Farooq; Laatsch, Hartmut

doi:10.1002/prac.19983400702

Cited by 62 publications

(50 citation statements)

References 120 publications

(10 reference statements)

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“…Since the discovery that the marine basidiomycete Halocyphina villosa produced the bioactive compound siccayne in 1981 (Kupka et al 1981), our knowledge of their potential for production of secondary metabolities has increased dramatically. The result has been a number of extensive reviews of the subject: Biabani andLaatsch (1998), Miller (2000), Verbist et al (2000), Faulkner (2002, Jensen and Fenical (2002), Lin and Zhou (2003), Bugni and Ireland (2004), Jones (2008) and Ebel (2010). The late Dr John Faulkner for a number of years reviewed the new secondry metabolites produced by marine microorganisms, which included marine fungi (Faulkner 2002, and references included therein) and this is being continued by Peter Proksch in Fungal Diversity (Aly et al 2010;Debbab et al 2011).…”

Section: Bioactive Compoundsmentioning

confidence: 98%

Fifty years of marine mycology

Jones

2011

Fungal Diversity

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Marine fungi have been widely studied over the past millennium and considerable progress has been made in documenting their phylogeny, biodiversity, ultrastructure, ecology, physiology and their ability to cause decay of lignocellulosic compounds. These studies have generated a wealth of publications and this review will focus primarily on research undertaken since 1995. During this period new topics have attracted marine mycologists especially: algicolous and manglicolous fungi, deep sea fungi, planktonic fungi, endophytes of marine plants, and the screening of taxa for new chemical structures and bioactive compounds. This review will also highlight areas that warrant further investigation, including surveys for marine fungi in Africa, artic waters and south America, more detailed studies of their physiology and biochemistry, and to determine the marine origin of so called "marine derived" fungi.

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Section: Bioactive Compoundsmentioning

confidence: 98%

Fifty years of marine mycology

Jones

2011

Fungal Diversity

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“…Until recently, only modest attention has been devoted toward metabolites from marine (or marinederived) fungi. To date, about 300 new compounds from marine-derived fungi have been described and reviewed [4,6,12,33,60]. These documented discoveries clearly show that marine fungi are a proliWc source of structurally unique and biologically active natural compounds.…”

Section: Biotechnological Potential Of Sponge-associated Microbesmentioning

confidence: 98%

Diversity and biotechnological potential of the sponge-associated microbial consortia

Wang

2006

J IND MICROBIOL BIOTECHNOL

189

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Sponges are well known to harbor diverse microbes and represent a significant source of bioactive natural compounds derived from the marine environment. Recent studies of the microbial communities of marine sponges have uncovered previously undescribed species and an array of new chemical compounds. In contrast to natural compounds, studies on enzymes with biotechnological potential from microbes associated with sponges are rare although enzymes with novel activities that have potential medical and biotechnological applications have been identified from sponges and microbes associated with sponges. Both bacteria and fungi have been isolated from a wide range of marine sponge, but the diversity and symbiotic relationship of bacteria has been studied to a greater extent than that of fungi isolated from sponges. Molecular methods (e.g., rDNA, DGGE, and FISH) have revealed a great diversity of the unculturable bacteria and archaea. Metagenomic approaches have identified interesting metabolic pathways responsible for the production of natural compounds and may provide a new avenue to explore the microbial diversity and biotechnological potential of marine sponges. In addition, other eukaryotic organisms such as diatoms and unicellular algae from marine sponges are also being described using these molecular techniques. Many natural compounds derived from sponges are suspected to be of bacterial origin, but only a few studies have provided convincing evidence for symbiotic producers in sponges. Microbes in sponges exist in different associations with sponges including the true symbiosis. Fungi derived from marine sponges represent the single most prolific source of diverse bioactive marine fungal compounds found to date. There is a developing interest in determining the true diversity of fungi present in marine sponges and the nature of the association. Molecular methods will allow scientists to more accurately identify fungal species and determine actual diversity of sponge-associated fungi. This is especially important as greater cooperation between bacteriologists, mycologists, natural product chemists, and bioengineers is needed to provide a well-coordinated effort in studying the diversity, ecology, physiology, and association between bacteria, fungi, and other organisms present in marine sponges.

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“…Each year large numbers of fungal isolates are selected from a range of different habitats and geographic locations, in a more-or-less random manner (Dreyfuss and Chapela, 1994;Pel aez et al, 1998;Schultz et al, 2002;Wildman, 1995). The blind nature of the selection process is a ratelimiting step in natural product discovery because it is rare that any of the compounds produced by fungi, indiscriminately selected from the natural environment, will show useful biological activities (Biabani and Laatsch, 1998;Dreyfuss and Chapela, 1994;Gloer, 1995;Langley, 1997;M€ oller et al, 1996;Monaghan et al, 1995;Talbot et al, 1996;Wildman, 1995).…”

Section: Introductionmentioning

confidence: 98%