Advances in cell membrane-camouflaged nano-carrier for photothermal therapy

Ming-hui, 昝明辉 Zan; Lang, 饶 浪 Rao; Wei, 谢 伟 Xie; Dao-ming, 朱道明 Zhu; Xing-wang, 郄兴旺 Qie; Wen-fei, 董文飞 Dong; Wei, 刘 威 Liu

doi:10.3788/co.20181103.0392

Cited by 2 publications

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“…Cell membranes derived from red blood cells, various immune cells, stem cells or cancer cells are extracted and extruded to form vesicles, which can then be used to coat a variety of payloads such as polymers, contrasting agents, cancer drugs, etc. [7][8][9][10][11][12][13][14][15][23][24][25][26][27][28][29][30]. However, in all of the applications mentioned above, the cell membranes are mainly used as carriers of active compounds, and the membrane itself has only been exploited for its biomimetic capability.…”

Section: Discussionmentioning

confidence: 99%

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Plasma Membrane-Derived Liposomes Exhibit Robust Antiviral Activity against HSV-1

Bhattacharya

Yadavalli

et al. 2022

Viruses

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Plasma membranes host a plethora of proteins and glycans on their outer surface that are exploited by viruses to enter the cells. In this study, we have utilized this property to limit a viral infection using plasma membrane-derived vesicles. We show that plasma membrane-derived liposomes are prophylactically and therapeutically competent at preventing herpes simplex virus type-1 (HSV-1) infection. Plasma membrane liposomes derived from human corneal epithelial (HCE) cells, which are natural targets of HSV-1 infection, as well as Vero and Chinese hamster ovary (CHO) cells were used in this study. Our study clearly demonstrates that HCE and Vero-derived cellular liposomes, which express the viral entry-specific cell surface protein receptors, exhibit robust antiviral activity especially when compared to CHO-derived liposomes, which lack the relevant HSV-1 entry receptors. Further experimentation of the plasma membrane-derived liposomes with HSV type-2 (HSV-2) and pseudorabies virus yielded similar results, indicating strong potential for the employment of these liposomes to study viral entry mechanisms in a cell free-environment.

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Section: Discussionmentioning

confidence: 99%

“…Particles of lipid origin, such as liposomes, are very commonly used as drug carriers [7][8][9][10]. These liposomes are biocompatible, non-toxic and can be modified based on the necessity of the application.…”

Section: Introductionmentioning

confidence: 99%