Advances in celiac disease testing

Pasinszki, Tibor; Krebsz, Melinda

doi:10.1016/bs.acc.2019.03.001

Cited by 16 publications

(9 citation statements)

References 61 publications

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“…Interestingly, electrochemical biosensors, except for CE and the recently constructed electrode array ECS, have not been developed for CTX detection in fish tissue, possibly due to the lack of sufficient amounts and types of CTX antibodies. Solving the antibody problem in the future may stimulate large-scale development in this field, especially since antibody-based methods offer the potential for miniaturization and development of portable devices and POC tests [ 139 , 140 , 141 ]. The application of LC-MS/MS for CTXs detection was an important break-through in CTX screening, because this method is sufficiently sensitive, selective, and unique in providing toxin profiles.…”

Section: Outlook and Conclusionmentioning

confidence: 99%

Advances in Detecting Ciguatoxins in Fish

Pasinszki

Lako

Dennis

2020

Toxins

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Ciguatera fish poisoning (CFP) is currently the most common marine biotoxin food poisoning worldwide, associated with human consumption of circumtropical fish and marine invertebrates that are contaminated with ciguatoxins. Ciguatoxins are very potent sodium-channel activator neurotoxins, that pose risks to human health at very low concentrations (>0.01 ng per g of fish flesh in the case of the most potent Pacific ciguatoxin). Symptoms of CFP are nonspecific and intoxication in humans is often misdiagnosed. Presently, there is no medically approved treatment of ciguatera. Therefore, to mitigate the risks of CFP, reliable detection of ciguatoxins prior to consumption of fish tissue is acutely needed, which requires application of highly sensitive and quantitative analytical tests. During the last century a number of methods have been developed to identify and quantify the concentration of ciguatoxins, including in vivo animal assays, cell-based assays, receptor binding assays, antibody-based immunoassays, electrochemical methods, and analytical techniques based on coupling of liquid chromatography with mass spectrometry. Development of these methods, their various advantages and limitations, as well as future challenges are discussed in this review.

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Section: Outlook and Conclusionmentioning

confidence: 99%

Advances in Detecting Ciguatoxins in Fish

Pasinszki

Lako

Dennis

2020

Toxins

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“…Through such modifications, these electrodes improve their properties and may be used in numerous applications in various fields, such as environmental measurements (to determine heavy metals), foods and agriculture (to detect certain compounds in foods or pesticide in soil), forensic (to determine toxic compounds or drugs), and clinical (to determine biomarkers for celiac disease or prostate cancer) [60,[68][69][70][71].…”

Section: Development Of Screen-printed Based Sensorsmentioning

confidence: 99%

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

Bounegru

Apetrei

2020

Catalysts

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This paper aims to revise research on carbonaceous nanomaterials used in developing sensors. In general, nanomaterials are known to be useful in developing high-performance sensors due to their unique physical and chemical properties. Thus, descriptions were made for various structural features, properties, and manner of functionalization of carbon-based nanomaterials used in electrochemical sensors. Of the commonly used technologies in manufacturing electrochemical sensors, the screen-printing technique was described, highlighting the advantages of this type of device. In addition, an analysis was performed in point of the various applications of carbon-based nanomaterial sensors to detect analytes of interest in different sample types.

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“…This is particularly valuable in children for whom blood collection may be challenging [ 5 ]. A limited number of studies have explored the feasibility of detecting autoantibodies in saliva [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The majority of studies focused on the detection of antibodies to citrullinated cyclic peptides (CCPs) which are a hallmark in the diagnosis of RA.…”

Section: Introductionmentioning

confidence: 99%

Detection of Autoantibodies in Saliva as New Avenue for the Diagnosis and Management of Autoimmune Patients

Sciascia¹,

Bentow²,

Radin³

et al. 2022

Diagnostics

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(1) Background: Autoimmune diseases are characterized by autoantibodies directed to a large number of antigenic targets and are measured using serum as sample matrix. Although serum is a very common specimen type, it comes with certain drawbacks. Most importantly, it depends on venous puncture and requires medical personnel for sampling. This is of particular importance in light of the limited healthcare access of patients with autoimmune diseases during the COVID-19 pandemic. Consequently, alternative sample matrices are being explored for the measurement of autoantibodies. Our study aimed to establish the feasibility of measuring autoantibodies in saliva samples using a novel and highly sensitive method for the detection of autoantibodies. (2) Methods: A total of 48 serum/saliva pairs were collected and tested using a novel particle-based multi-analyte technology (PMAT) system for the presence of a wide range of autoantibodies. (3) Results: A high level of correlation was observed between the results obtained with serum and saliva (Spearman’s rho = 0.725). Study participants clearly preferred saliva over serum sampling as part of the usability assessment. (4) Conclusions: Saliva represents a promising alternative sample matrix for the detection of autoantibodies. The usability study showed a clear preference of saliva over serum as a sample matrix.

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Advances in celiac disease testing

Cited by 16 publications

References 61 publications

Advances in Detecting Ciguatoxins in Fish

Advances in Detecting Ciguatoxins in Fish

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

Detection of Autoantibodies in Saliva as New Avenue for the Diagnosis and Management of Autoimmune Patients

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