Advances in Cardiac Biomarkers of Acute Coronary Syndrome

Saenger, Amy K.; Korpi-Steiner, Nichole

doi:10.1016/bs.acc.2016.07.001

Cited by 10 publications

(10 citation statements)

References 174 publications

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“…Characterized by acute plaque rupture and thrombosis formation in the coronary arteries, patients with ACS usually have higher risk for the development of heart failure (HF) and death [4–6]. Biomarkers such as cardiac troponin and B-type natriuretic peptide (BNP) play important roles for risk estimation in ACS patients [7,8]. Besides, recent studies indicate that other biomarkers such as soluble suppression of tumorigenicity-2 (sST2) concentration also confer prognostic value in patients with ACS [9,10].…”

Section: Introductionmentioning

confidence: 99%

Short-term and long-term prognostic value of circulating soluble suppression of tumorigenicity-2 concentration in acute coronary syndrome: a meta-analysis

2019

Bioscience Reports

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Background: Higher circulating soluble suppression of tumorigenicity-2 (sST2) concentration is suggested as a marker of prognosis in many cardiovascular diseases. However, the short-term and long-term prognostic value of sST2 concentration in acute coronary syndrome (ACS) remains to be summarized. Methods: A meta-analysis of follow-up studies was performed. Studies were identified via systematic search of databases including PubMed, Cochrane’s Library, and Embase. A fixed- or random-effect model was applied according to the heterogeneity. We reported the prognostic value of sST2 concentration for all-cause mortality, heart failure (HF) events, and major adverse cardiovascular events (MACEs) within 1 month after hospitalization and during subsequent follow-up. Results: Twelve studies with 11690 ACS patients were included. Higher baseline sST2 concentration as continuous variables predicte the increased risk of all-cause mortality (risk ratio [RR]: 3.16, P=0.002), HF events (RR: 1.48, P<0.001), and MACEs (RR: 1.47, P<0.001) within 1 month after hospitalization, which is consistent with the results with sST2 concentration as categorized variables (RR = 2.14, 2.89, and 2.89 respectively, P all <0.001). Moreover, higher baseline sST2 concentration as continuous variables predict the increased risk of all-cause mortality (RR: 2.20, P<0.001), HF events (RR: 1.39, P<0.001), and MACEs (RR: 1.53, P=0.02) during subsequent follow-up. Meta-analysis with sST2 concentration as categorized variables retrieved similar results (RR = 2.65, 2.59, and 1.81 respectively, P all <0.001). Conclusions: Higher circulating sST2 concentration at baseline predicts poor clinical outcome in ACS patients.

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Section: Introductionmentioning

confidence: 99%

Short-term and long-term prognostic value of circulating soluble suppression of tumorigenicity-2 concentration in acute coronary syndrome: a meta-analysis

2019

Bioscience Reports

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“…To anticipate possible optical interferences from hemoglobin in blood-contaminated samples, assays were performed in buffer containing 1.5 mg/mL hemoglobin ( Figure 5 ). The concentration was chosen to model that found in hemolyzed blood [ 39 ]. Indeed, fluorescence measurements were decreased in the presence of hemoglobin.…”

Section: Resultsmentioning

confidence: 99%

Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts

Suresh

Byers²,

Rajesh³

et al. 2022

Diagnostics

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The classification of pancreatic cyst fluids can provide a basis for the early detection of pancreatic cancer while eliminating unnecessary procedures. A candidate biomarker, gastricsin (pepsin C), was found to be present in potentially malignant mucinous pancreatic cyst fluids. A gastricsin activity assay using a magnetic bead-based platform has been developed using immobilized peptide substrates selective for gastricsin bearing a dimeric rhodamine dye. The unique dye structure allows quantitation of enzyme-cleaved product by both fluorescence and surface enhanced Raman spectroscopy (SERS). The performance of this assay was compared with ELISA assays of pepsinogen C and the standard of care, carcinoembryonic antigen (CEA), in the same clinical sample cohort. A retrospective cohort of mucinous (n = 40) and non-mucinous (n = 29) classes of pancreatic cyst fluid samples were analyzed using the new protease activity assay. For both assay detection modes, successful differentiation of mucinous and non-mucinous cyst fluid was achieved using 1 µL clinical samples. The activity-based assays in combination with CEA exhibit optimal sensitivity and specificity of 87% and 93%, respectively. The use of this gastricsin activity assay requires a minimal volume of clinical specimen, offers a rapid assay time, and shows improvements in the differentiation of mucinous and non-mucinous cysts using an accurate standardized readout of product formation, all without interfering with the clinical standard of care.

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“…In addition, the patient's copeptin level was above 40 pmol/L, indicating nephrogenic DI. However, in the United States, copeptin is a research use only test that the Food and Drug Administration has not approved because there is no reliable plasma copeptin assay except in research labs [11]. As a result, the diagnosis should not be based solely on the level of serum copeptin.…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?

Shrestha¹,

Jasaraj²,

Dhital³

et al. 2022

Cureus

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Diabetes insipidus (DI) is a rare disease characterized by hypotonic urine output and polydipsia. We report the case of a 50-year-old male admitted for diabetic ketoacidosis (DKA) in an intensive care unit with sepsis and alcoholic pancreatitis who later developed DI. He had a high copeptin level of >21.4 pmol/L, suggesting DI of nephrogenic origin. At presentation, he had DKA-associated osmotic diuresis. His later finding of elevated copeptin suggesting partial nephrogenic DI created a diagnostic enigma.

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Advances in Cardiac Biomarkers of Acute Coronary Syndrome

Cited by 10 publications

References 174 publications

Short-term and long-term prognostic value of circulating soluble suppression of tumorigenicity-2 concentration in acute coronary syndrome: a meta-analysis

Short-term and long-term prognostic value of circulating soluble suppression of tumorigenicity-2 concentration in acute coronary syndrome: a meta-analysis

Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts

A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?

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