Advances in Brain Metastases Presented at the American Society of Clinical Oncology 2016 Annual Meeting: Part I

Chen, Lucy F.; Patel, Jyoti D.; Lukas, Rimas V.

doi:10.2217/fon-2016-0341

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Important advances in our understanding of brain metastases are underway [ 1 , 2 ]. While there have been many recent reviews of brain metastases [ 3 – 6 ] as well as more focused reviews on non-small cell lung cancer (NSCLC) brain metastases [ 7 – 9 ] there has been a paucity of contemporary reviews focusing on small cell lung cancer (SCLC) brain metastases.…”

Section: Introductionmentioning

confidence: 99%

State-of-the-art considerations in small cell lung cancer brain metastases

et al. 2017

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BackgroundSmall cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments.DesignA comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed.ResultsSCLC brain metastases continue to have a poor prognosis. Both unique aspects of SCLC brain metastases as well as features seen more universally across other solid tumor brain metastases are discussed. Systemic therapeutic studies and radiotherapeutic approaches are reviewed.ConclusionsA clearer understanding of SCLC brain metastases will help lay the framework for studies which will hopefully translate into meaningful therapeutic options for these patients.

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