2012
DOI: 10.1007/s13346-012-0070-6
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Advances in biomimetic regeneration of elastic matrix structures

Abstract: Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precursors and assemble them into mature crosslinked structures has hindered the development of functional tissue-engineered constructs that exhibit the structure and biomechanics of normal native elasti… Show more

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Cited by 29 publications
(37 citation statements)
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References 396 publications
(453 reference statements)
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“…Unfortunately, adults cells cannot regenerate lost elastic fibers on their own as the microfibrillar assembly is lacking 23 . Furthermore, degraded elastic lamina can release elastin degradation products (EDPs) that are chemokines for inflammatory cells and modulate M1/M2 macrophage polarization 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, adults cells cannot regenerate lost elastic fibers on their own as the microfibrillar assembly is lacking 23 . Furthermore, degraded elastic lamina can release elastin degradation products (EDPs) that are chemokines for inflammatory cells and modulate M1/M2 macrophage polarization 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Collagen, which primarily imparts stiffness to soft tissues, is generated prolifically by cells (SMCs, fibroblasts) well into adulthood and in response to injury [25]. However, adult cells are inherently poor in their ability to synthesize elastin and crosslink it into a mature matrix, although this can be overcome by exogenous delivery of elastogenic biomolecules [26], Therefore, our long-term goal is to develop modalities for localized, controlled, and sustained delivery of HA-o to tissue sites of proteolytic disease such as within AAA tissues towards inducing biomimetic cellular regeneration of the elastic matrix, which poorly occurs naturally.…”
Section: Discussionmentioning
confidence: 99%
“…Despite recent progress in the field of vascular tissue engineering, elastin synthesis and deposition by vascular SMCs within 3D constructs remain a formidable challenge. 18,66 This is partially due to the highly reduced ability of adult SMCs, at both transcription and translation levels, to synthesize, release, and deposit mature elastin. Thus, the overarching goal of cellular or tissue engineering approaches is to stimulate these adult SMCs, using an optimal combination of biochemical and biomechanical cues, to deposit mature and crosslinked elastin within blood vessels.…”
Section: Elastin Synthesis and Deposition By Ha-smcsmentioning
confidence: 99%