Advances in Biomaterials for Breast Reconstruction

Abstract

Breast cancer is one of the most commonly diagnosed malignancies in women. Along with increasing demands for breast reconstruction, the attention given to the psychological and aesthetic benefits of breast reconstruction has also increased. As breast reconstruction and augmentation demands increase, biomaterials for breast reconstruction are being developed, and the related industry is growing quickly worldwide. Among the various biomaterials used for breast enlargement, breast implants have undergone a remarkable evolution since the 1960s. Despite unsatisfactory results and unexpected complications, research dedicated to achieving an ideal breast implant has progressed. In accordance with attention to tissue engineering, a three-dimensional (3D) bioprinting technique for breast tissue regeneration has emerged to overcome the current limitations of breast biomaterials. Along with solid implants, injectable liquid-type fillers are also part of ongoing studies.

Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds

“…In vitro , these cells have a larger and flatter body as compared to healthy cells with enhanced actin stress fibers. , They are also characterized by large nuclei, multinuclei, and chromatin reorganization and are relatively more granulated than their nonsenescent counterpart. − Several of the age -associated diseases require treatments in the form of replacement, support, or intervention using some form of biomaterials. It could range from the insertion of pacemakers, stents, plates, screws, etc., to breast implants, catheters, dental implants, and even contact lenses . With the decline in overall functionality and regenerative capabilities of geriatric populations, the success rates of biomaterials also fall .…”

“…69−71 Several of the age -associated diseases require treatments in the form of replacement, support, or intervention using some form of biomaterials. It could range from the insertion of pacemakers, 72 stents, plates, screws, 73 etc., to breast implants, 74 catheters, 75 dental implants, 10 and even contact lenses. 76 With the decline in overall functionality and regenerative capabilities of geriatric populations, the success rates of biomaterials also fall.…”

Flexible, Biocompatible PET Sheets: A Platform for Attachment, Proliferation and Differentiation of Eukaryotic Cells

“…The development of flexible surfaces is essential to create soft spatial topologies that allow one to study mechanical strains on cells, or to graft cells into moving organs subjected to topological constrains, like muscles, for example [1][2][3]. Indeed, biomaterials play a major role in modern medicine; they can be employed as part of reconstructive implants [4], implanted sensing objects [5], and a system for site-specific drug delivery [6]. Advances in biomaterials have led to non-toxic implants as well as those that are specifically designed to elicit particular functions within the host [7,8].…”