Advances in batch culture fermented Coriolus versicolor medicinal mushroom for the production of antibacterial compounds

Duvnjak, Dunja; Pantić, Milena; Pavlović, Vladimir B.; Nedović, Viktor; Lević, Steva; Matijašević, Danka; Sknepnek, Aleksandra; Nikšić, Miomir

doi:10.1016/j.ifset.2015.12.028

Cited by 31 publications

(55 citation statements)

References 54 publications

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“…4 filter paper and the residue was reextracted two more times under the same conditions. The resulting solutions were combined and the solvent was evaporated completely under vacuum in an R‐II rotavapor (Buchi, Switzerland) [6].…”

Section: Methodsmentioning

confidence: 99%

“…Using mushroom cultivation in a liquid medium with a defined composition, constant quality could be provided by excluding the influence of the unknown mineral composition of the substrate. [6].…”

Section: Introductionmentioning

confidence: 99%

“…Since it is not possible to interrupt the evolution of microorganisms, scientists are forced to search for new antimicrobial substances from various sources [23,24]. The previous research confirmed antioxidative and antibacterial activities of intracellular and extracellular polysaccharides and polysaccharopeptides of Coriolus versicolor medicinal mushroom [6,25,26]. A recently published work showed significant differences in the antibacterial activity of the methanol extract of selenized C. versicolor when different sources of selenium (oganic selenourea and inorganic sodium selenite) were applied during cultivation [15].…”

Section: Introductionmentioning

confidence: 99%

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Influence of selenium yeast on the growth, selenium uptake and mineral composition of Coriolus versicolor mushroom

et al. 2020

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The ability of Coriolus versicolor medicinal mushroom to grow and accumulate selenium during submerged cultivation in a selenium‐fortified medium is examined in this paper. For selenium supplementation, commercial selenium yeast was used. Control, nonenriched sample and reference cultures cultivated in the medium enriched with commercial yeast Saccharomyces cerevisiae were also prepared. The mushroom demonstrated a high ability to accumulate selenium from the added source (around 970 and 1,300 µg/g of dry mycelium weight for samples enriched with selenium in a concentration of 10 and 20 mg Se/L, respectively). The addition of selenium significantly (p ≤ .05) increased the biomass yield, whereas the addition of nonenriched yeast had no significant (p ≤ .05) impact. Furthermore, regression analysis showed statistically significant (p ≤ .05) and positive correlations between the content of Se and Fe (r = .92), Se and Cu (r = .92), Se and Mn (r = .98), and Se and Sr (r = .96), suggesting that selenium incorporation was followed by incorporation of these elements, and led to mineral enrichment of the obtained mycelium. Methanol extracts prepared from mycelium biomass demonstrated a better inhibitory effect on Gram‐positive bacterial strains with minimal inhibitory concentrations between <0.3125 and 40 mg/ml. The obtained results showed that selenium yeast could be used for obtaining a potential novel food supplement: mushroom biomass with high selenium content and enhanced mineral composition.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of selenium yeast on the growth, selenium uptake and mineral composition of Coriolus versicolor mushroom

et al. 2020

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“…The shiitake mushroom Lentinula edodes is considered as antioxidant agent and good source of mineral elements and has efficient levels of carbohydrates, proteins, lipids, and crude fibers (Jang et al 2015). Extracts of mycelia and biomass of Coriolus versicolor have inhibitory effect against drug-resistant bacteria (Zaidi et al 2013, Duvnjak et al 2016. and spent mushroom substrates of Lentinula edodes have antibacterial activity against Gram positive and Gram negative pathogenic bacteria (Zepeda-Bastida et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…and spent mushroom substrates of Lentinula edodes have antibacterial activity against Gram positive and Gram negative pathogenic bacteria (Zepeda-Bastida et al 2016). Furthermore, exopolysaccharides of Coriolus versicolor exhibited strong antibacterial activities (Duvnjak et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Antagonistic role of hypha and cell-free culture filtrates of medicinal mushrooms to Verticillium sp. and Pythium sp. fungal pathogens

Owaid¹

2017

CREAM

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The aim of this experiment is to study the effects of interspecific interactions of three medicinal mushrooms (Coriolus versicolor, Hericium erinaceus and Lentinula edodes) on the growth of two fungal pathogens (Verticillium sp. and Pythium sp.) using dual culture plate assay. In single cultures in PDA plates, overgrowth of mushrooms was completed after 5, 11, and 12 days for C. versicolor, L. edodes, and H. erinaceus respectively. Generally, C. versicolor presented the fastest mycelial growth in dual culture after incubation for ten days. From another side, the best significant (p<0.01) inhibition was 67.13% and 65.28% by hyphal of C. versicolor toward Verticillium sp. and Pythium sp. respectively. While, the lower inhibition activity (26.76%) was recorded on Verticillium sp. plate by mycelia of H. erinaceus during 5 days. After 15 days, metabolites of fungi showed only on edges of L. edodes mushroom colonies in form shining golden drops. The solid medium of cell-free culture filtrate of C. versicolor exhibited best inhibition percentage of 6.67% against Verticillium sp. fungus significantly (p<0.01). While, Pythium sp. recorded the lower inhibition percentage on solid medium of L. edodes filtrate (2.27%). In general, Pythium sp. was more sensitive than Verticillium sp. on the solid media of cell-free culture filtrate of all mushrooms.

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Selenium‐enriched Coriolus versicolor mushroom biomass: potential novel food supplement with improved selenium bioavailability

et al. 2019

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BACKGROUND The ability of Coriolus versicolor medicinal mushroom to accumulate and transform selenium from selenourea and sodium selenite into an organic form – l‐selenomethionine – during growth in liquid medium is examined in this paper. Additionally, the impact of supplementation on biological activity of the selenated mushroom methanol extracts, as well as their chemical composition, is studied. RESULTS Selenium accumulation was more efficient with sodium selenite application, but biomass yield was significantly lower (1.89 g DW L−1) compared to samples enriched with selenourea (4.48 g DW L−1). Mushroom sample obtained after growing in liquid medium with selenourea had significantly higher l‐selenomethionine content compared to the sample grown in medium with sodium selenite. Selenium‐enriched methanol extracts of C. versicolor mushroom showed improved antimicrobial and antioxidant activities compared to non‐enriched extract. CONCLUSION Our results suggest that C. versicolor mushroom cultivated in liquid culture enriched with selenourea can be used for the production of novel food supplements with improved selenium bioavailability. More than 30% of total accumulated selenium from selenourea is transformed into l‐selenomethionine. Differences in biological activity of methanol extracts can be explained not only by different selenium content but also by the differences in chemical composition of extracts. © 2019 Society of Chemical Industry

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Advances in batch culture fermented Coriolus versicolor medicinal mushroom for the production of antibacterial compounds

Cited by 31 publications

References 54 publications

Influence of selenium yeast on the growth, selenium uptake and mineral composition of Coriolus versicolor mushroom

Influence of selenium yeast on the growth, selenium uptake and mineral composition of Coriolus versicolor mushroom

Antagonistic role of hypha and cell-free culture filtrates of medicinal mushrooms to Verticillium sp. and Pythium sp. fungal pathogens

Selenium‐enriched Coriolus versicolor mushroom biomass: potential novel food supplement with improved selenium bioavailability

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