Advances in asthma in 2017: Mechanisms, biologics, and genetics

Grayson, Mitchell H.; Feldman, Scott; Prince, Benjamin; Patel, Priya; Matsui, Elizabeth C.; Apter, Andrea J.

doi:10.1016/j.jaci.2018.08.033

Cited by 39 publications

(27 citation statements)

References 95 publications

(234 reference statements)

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“…e cell types involved in the pathological process of asthma include 2 cells, 17 cells, NK cells, antigen presenting cells, B cells, etc. [9][10][11][12][13]. As an important natural immune cell, NK cells are the third type of lymphocytes along with T cells and B cells.…”

Section: Discussionmentioning

confidence: 99%

Altered Frequency of NK Cells and Treg Cells by Astragalus Polysaccharide Combined with Budesonide in Asthma Model Mice

Zhang

2020

Advances in Polymer Technology

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Objective. We investigated the efficacy of astragalus polysaccharide (APS) combined with budesonide and the effect on expressions of peripheral NK cells and Treg cells and the molecular mechanism in mice with bronchial asthma. Methods. In this study, we established a mouse model of asthma. Four groups of BaLB/C mice were developed; control group had no asthma induction, and the other three groups of mice were sensitized by OVA (Ovalbumin), OVA + budesonide, and OVA + APS + budesonide. Flow cytometry was used to determine the proportion of NK cells and Treg cells. Levels of cytokines IL-4 and IL-10 were detected using RT-PCR and ELISA. Results. Asthma mice treated with APS + budesonide showed alleviated airway resistance compared to model mice (P<0.05). The percentage of dendritic cells (DCs) was reduced (P<0.05), while anti-inflammatory NK cells and Treg cells significantly increased after APS + budesonide treatment (P<0.05). Further, APS + budesonide treatment resulted in improvements in IL-4 and IL-10 mRNA and protein levels (P<0.05). Conclusion. APS combined with budesonide medication may regulate expressions of DCs cells and related cytokines, reliving clinical symptom of bronchial asthma.

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Section: Discussionmentioning

confidence: 99%

Altered Frequency of NK Cells and Treg Cells by Astragalus Polysaccharide Combined with Budesonide in Asthma Model Mice

Zhang

2020

Advances in Polymer Technology

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“…Periostin, an extracellular matrix protein secreted by airway epithelial cells in response to IL-13 that regulates epithelial-mesenchymal interactions (Fitzpatrick 2015), has been associated with T2-high eosinophilic asthma (Grayson et al 2018). Periostin expression is increased in the asthmatic airway (Lopez-Guisa et al 2012).…”

Section: Blood Cells and Serum Biomarkersmentioning

confidence: 99%

“…Although all advantages of serum biomarkers, it is important to remember that peripheral blood studies often do not reflect airway biology, and therefore peripheral blood biomarkers might not represent physiologic mechanisms in the airways (Grayson et al 2018).…”

Section: Blood Cells and Serum Biomarkersmentioning

confidence: 99%

Biomarkers of Bronchial Asthma

Kunč¹,

Fabry²,

Lucanska³

et al. 2020

Physiol Res

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Asthma is a complex disease with a variable course. Efforts to identify biomarkers to predict asthma severity, the course of disease and response to treatment have not been very successful so far. Biomarker research has expanded greatly with the advancement of molecular research techniques. An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient. An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient - exhaled breath analysis, blood cells and serum biomarkers, sputum cells and mediators and urine metabolites could be potential biomarkers of asthma bronchiale. Unfortunately, at the moment, an ideal biomarker doesn’t exist and the overlap between the biomarkers is a reality. Using panels of biomarkers could improve probably the identification of asthma endotypes in the era of precision medicine.

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“…In Table 1, we list the currently proposed candidate biomarkers as well as their potential sampling compartment, advantages, disadvantages and utility for clinical use. [53]. Mouse models suggest a role of periostin in subepithelial fibrosis, eosinophil recruitment, and mucus production from goblet cells [54].…”

Section: Current and Future Asthma Biomarkersmentioning

confidence: 99%

Airway epithelial cell damage in asthma: mechanisms and biomarkers

Yang

Jia

et al. 2020

Preprint

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Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing different phenotypes, including severe asthma. The airway epithelium is a major site of complex pathological changes in severe asthma due, in part, to activation of inflammatory and immune mechanisms in response to noxious agents. Current imaging procedures are unable to accurately measure epithelial and airway remodeling. Damage of airway epithelial cells occurs is linked to specific phenotypes and endotypes which provides an opportunity for the identification of biomarkers reflecting epithelial, and airway, remodeling. Identification of patients with more severe epithelial disruption using biomarkers may also provide personalized therapeutic opportunities and/or markers of successful therapeutic intervention. Here, we review the evidence for ongoing epithelial cell dysregulation in the pathogenesis of asthma, the sentinel role of the airway epithelium and how understanding these molecular mechanisms provides the basis for the identification of candidate biomarkers for asthma prediction, prevention, diagnosis, treatment and monitoring.

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Advances in asthma in 2017: Mechanisms, biologics, and genetics

Cited by 39 publications

References 95 publications

Altered Frequency of NK Cells and Treg Cells by Astragalus Polysaccharide Combined with Budesonide in Asthma Model Mice

Altered Frequency of NK Cells and Treg Cells by Astragalus Polysaccharide Combined with Budesonide in Asthma Model Mice

Biomarkers of Bronchial Asthma

Airway epithelial cell damage in asthma: mechanisms and biomarkers

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