Advances in asthma genetics

Bansal, Mayank; Garg, Mayank; Agrawal, Anurag

doi:10.1016/bs.adgen.2020.11.001

Cited by 8 publications

(17 citation statements)

References 83 publications

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“…16,17 The methodological approaches and study design in the field of asthma genetics since its beginning more than 30 years ago have been extensively reviewed elsewhere. 18,19 The first decades were characterized by hypothesis-driven approaches that evolved into genome-wide association studies (GWAS) 18,19 triggered by the numerous limitations of the former strategies and the development of genome-scale genotyping platforms. 18,19 The main findings of the GWAS of asthma susceptibility published until 2019 have been previously described in detail, which have revealed the association of nearly 40 genomic regions.…”

Section: A S Thma G Ene Tic Smentioning

confidence: 99%

“…18,19 The first decades were characterized by hypothesis-driven approaches that evolved into genome-wide association studies (GWAS) 18,19 triggered by the numerous limitations of the former strategies and the development of genome-scale genotyping platforms. 18,19 The main findings of the GWAS of asthma susceptibility published until 2019 have been previously described in detail, which have revealed the association of nearly 40 genomic regions. 18,19 To the best of our knowledge, a total of 78 articles have reported results of genome-wide explorations in different asthma-related traits based on GWAS Catalog records (https://www.ebi.ac.uk/gwas/) by the time of writing (February 2022).…”

Section: A S Thma G Ene Tic Smentioning

confidence: 99%

“…18,19 The main findings of the GWAS of asthma susceptibility published until 2019 have been previously described in detail, which have revealed the association of nearly 40 genomic regions. 18,19 To the best of our knowledge, a total of 78 articles have reported results of genome-wide explorations in different asthma-related traits based on GWAS Catalog records (https://www.ebi.ac.uk/gwas/) by the time of writing (February 2022).…”

Section: A S Thma G Ene Tic Smentioning

confidence: 99%

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Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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Investigation of gene‐environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies have been applied, more recently using genome‐wide approaches. The best example to date is the major asthma locus on the 17q12‐21 chromosome region, viral infections, and airway epithelium processes where recent studies have shed much light on mechanisms in childhood asthma. However, there are challenges with the traditional single variant—single exposure interaction models, as they do not encompass the complexity and cumulative effects of multiple exposures or multiple genetic variants. As such, we need to redefine our traditional GxE thinking, and we propose in this review to expand the GxE concept by also evaluating other omics layers, such as epigenetics, transcriptomics, metabolomics, and proteomics. In addition, host factors such as age, gender, and other exposures are very likely to influence GxE effects and need firmly to be considered in future studies.

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Section: A S Thma G Ene Tic Smentioning

confidence: 99%

Section: A S Thma G Ene Tic Smentioning

confidence: 99%

Section: A S Thma G Ene Tic Smentioning

confidence: 99%

See 1 more Smart Citation

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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“…The heritability of childhood asthma reached as high as 82% (1). A long list of asthma-susceptibility genes has been identified (2,3). However, no consensus exists on which gene actually involves the pathogenesis of asthma, even with genome-wide association studies (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Genetically high angiotensin-converting enzyme concentrations causally increase asthma risk: A meta-analysis using Mendelian randomization

Hui

Hao

et al. 2022

Front. Med.

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ObjectivesThis meta-analysis aimed to test the association of angiotensin-converting enzyme (ACE) gene I/D polymorphism with asthma risk and circulating ACE changes.MethodsPublic literature retrieval, publication selection, and information extraction were completed independently by two investigators. Effect-size values are expressed as odds ratios (ORs) or standardized mean differences (SMDs) with a 95% confidence interval (95% CI).ResultsNineteen studies (2,888 patients and 9,549 controls) fulfilled the eligibility criteria. Overall investigations demonstrated that ACE gene I/D polymorphism was significantly associated with asthma risk under allelic (OR, 95% CI: 1.26, 1.08 to 1.48), homozygous genotypic (1.50, 1.09 to 2.06), and recessive (1.53, 1.24 to 1.89) models with moderate heterogeneity (I2 statistic: 64% to 79%). Subsidiary investigations recorded that race, matched status, asthma diagnosis, sample size, and age possibly accounted for the existence of significant heterogeneity. Relative to carriers with the II genotype, those with the DD genotype, ID genotype, and the combination of DD and ID genotypes had significantly higher concentrations of circulating ACE (WMD: 3.13, 2.07, and 2.83 U/L, respectively, p < 0.05). Adoption of Mendelian randomization analyses revealed that one unit increment in circulating ACE concentrations was found to be significantly associated with a 1.14-fold increased risk of asthma (95% CI: 1.02 to 4.24).ConclusionWe provided strong meta-analytical evidence supporting the causal implication of high circulating ACE concentrations in the development of asthma.

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“…The great efforts of the genetic research of asthma in the last three decades have resulted in the identification of numerous promising loci (4,5). Shi et al elegantly summarized the main contributions to this field in a recent publication in Annals of Translational Medicine, with the main focus on the genetic loci most commonly evidenced as candidates for asthma in the last 20 years (6).…”

mentioning

confidence: 99%

Unraveling the genetic architecture of asthma

Hernandez‐Pacheco¹

2022

Ann Transl Med

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Advances in asthma genetics

Cited by 8 publications

References 83 publications

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Genetically high angiotensin-converting enzyme concentrations causally increase asthma risk: A meta-analysis using Mendelian randomization

Unraveling the genetic architecture of asthma

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