Advances in application and innovation of microfluidic platforms for pharmaceutical analysis

Ma, Lijuan; Li, Nan; Wang, Jing; Ma, Chaofu; Hu, Xiaoyan; Li, Mingshuang; Wu, Zhisheng

doi:10.1016/j.trac.2023.116951

Cited by 8 publications

(1 citation statement)

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“…When modeling the OOC system, the cell type, microfluidic design carrying the proper nutrient delivery and oxygenation, ECM composition, shear stress, real-time sensor to monitor cell viability, proliferation, metabolic activity, readouts, and validation of results should be considered as shown in Figure . − Selecting the appropriate cell line, whether an induced pluripotent stem cell (iPSC) line or a primary cell line, is crucial for replicating the necessary cell–cell interactions to represent human biology accurately. Failure to incorporate specific cell lines for particular organs may lead to false positive results.…”

Section: Types Of Ooc Models For Nutraceutical Testingmentioning

confidence: 99%

Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

Farooqi,

Kang,

Choi

2023

ACS Omega

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The recent global wave of organic food consumption and the vitality of nutraceuticals for human health benefits has driven the need for applying scientific methods for phytochemical testing. Advanced in vitro models with greater physiological relevance than conventional in vitro models are required to evaluate the potential benefits and toxicity of nutraceuticals. Organ-onchip (OOC) models have emerged as a promising alternative to traditional in vitro models and animal testing due to their ability to mimic organ pathophysiology. Numerous studies have demonstrated the effectiveness of OOC models in identifying pharmaceutically relevant compounds and accurately assessing compound-induced toxicity. This review examines the utility of traditional in vitro nutraceutical testing models and discusses the potential of OOC technology as a preclinical testing tool to examine the biomedical potential of nutraceuticals by reducing the need for animal testing. Exploring the capabilities of OOC models in carrying out plant-based bioactive compounds can significantly contribute to the authentication of nutraceuticals and drug discovery and validate phytochemicals medicinal characteristics. Overall, OOC models can facilitate a more systematic and efficient assessment of nutraceutical compounds while overcoming the limitations of current traditional in vitro models.

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