Advances in antitumor nanomedicine based on functional metal–organic frameworks beyond drug carriers

Qin, Wei; Wu, Yihan; Liu, Fangfang; Cao, Jian; Liu, Jinliang

doi:10.1039/d1tb02518j

Cited by 13 publications

(2 citation statements)

References 169 publications

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“…. MOFs have been to date proposed for a large set of potential applications such as gas storage or separation, − catalysis, , sensing, , batteries, , and biomedicine. − Their high structural tunability, good biocompatibility, and biodegradability have made MOFs suitable candidates for controlled drug release, imaging, wound healing, etc. − …”

Section: Introductionmentioning

confidence: 99%

How Defects Impact the In Vitro Behavior of Iron Carboxylate MOF Nanoparticles

Ma,

Yu,

Nouar

et al. 2023

Chem. Mater.

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Nanoparticles of biocompatible iron carboxylate metal−organic frameworks (MOFs) or nanoMOFs are of great interest for biomedicine, in particular, for controlled drug release. However, little is known about the impact of their synthesis protocols on their defect content and the possible consequences in terms of physicochemical features and cytotoxicity. Here, we report for the first time how the defect content of the benchmark mesoporous iron trimesate MIL-100(Fe) (MIL stands for Materials of Institut Lavoisier) nanoparticles, with similar sizes but obtained from three different green synthesis routes, has a significant impact not only on their intrinsic porosity, stability in body fluids, drug loading capacity, and release but also shows a critical difference of in vitro toxicity and inflammatory response depending on the type of cell lines.

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Section: Introductionmentioning

confidence: 99%

How Defects Impact the In Vitro Behavior of Iron Carboxylate MOF Nanoparticles

Ma,

Yu,

Nouar

et al. 2023

Chem. Mater.

View full text Add to dashboard Cite

show abstract

“…[20][21][22][23] Except for these synthesized nanoparticles, chlorin e6 (Ce6) is also an outstanding porphyrin-based sonosensitizer to produce an abundant amount of ROS for the apoptosis of cancer cells under US treatment. [24][25][26][27] However, free Ce6 shows rapid clearance and poor accumulation in tumor tissues, which hinders its operating potential in biomedical engineering. Therefore, the modified Ce6 on nanomaterials has been created for efficient SDT.…”

Section: Introductionmentioning

confidence: 99%