Advances in antiobesity mechanisms of capsaicin

New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

“…Years of research of Zhu's team on capsaicin systems 16 , 17 , 18 , 19 , 20 , 21 have provided an important scientific basis for the prevention of cardiovascular metabolic diseases by spicy diets. Capsaicin also reportedly exerts anti-obesity effects by altering gut microbial composition, reducing intestinal permeability, and regulating the gut microbe–brain axis 22 . Capsaicin also activates TRPV1 ion channels to improve glucose homeostasis in the body, thereby preventing and improving prediabetic insulin resistance, diabetes, and its complications 23 .…”

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

“…Since the availability of in vivo human brown adipocytes is limited, we performed a small-scale chemical screening using ciBAs and identified several compounds that enhance browning. One of these compounds is capsaicin, a well-known pungent alkaloid found in chili pepper [ 99 ]. Animal studies have reported that capsaicin or capsinoid supplementation improved glucose metabolism in both rodents and humans [ 100 , 101 ].…”

“…A different report indicated that AdMSCs were differentiated into beige adipocytes on treatment with several growth factors and small molecules [ 105 ]. Drug discovery using the AdMSC-derived beige adipocytes identified several browning factors, indicating that AdMSCs are also useful for the identification of anti-obesity drugs and browning factors [ 99 , 105 , 106 ].…”

The synergic effects and mechanism of KGM–DMY complex in the prevention of obesity and enhancement of fatigue resistance in mice

“…Dietary interventions can alter the composition of the intestinal flora, 45 and thus affect the metabolism of the organism. 46 In order to investigate the variation of the main microorganisms in the microbial community, 16S rDNA sequence was performed. According to Fig.…”