Advances in anticancer alkaloid-derived metallo-chemotherapeutic agents in the last decade: Mechanism of action and future prospects

Ansari, Mohammad Fawad; Khan, Hina; Tabassum, Sartaj; Arjmand, Farukh

doi:10.1016/j.pharmthera.2022.108335

Cited by 5 publications

(4 citation statements)

References 128 publications

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“…[34] Metals coordination compounds show an increasing promising potential in cancer treatment. [35][36][37] Copper is an endogenous metal with flexible redox property, geometry, and variable oxidation state, which makes it easy to synthesize copper complexes. [38,39] Chemists and biochemists coordinate copper ions to organic ligands having various donor atoms (such as phosphorus, sulfur, oxygen, and nitrogen) to stimulate the cuproenzymes molecular environment and synthesize different copper complexes with various biological function.…”

Section: The Pharmacological Effects Of Copper Complexesmentioning

confidence: 99%

“…The disparate reactions of tumor cells and normal cells to copper have provided the basis for the development of copper complexes as potential anticancer agents [34] . Metals coordination compounds show an increasing promising potential in cancer treatment [35–37] . Copper is an endogenous metal with flexible redox property, geometry, and variable oxidation state, which makes it easy to synthesize copper complexes [38,39] .…”

Section: The Pharmacological Effects Of Copper Complexesmentioning

confidence: 99%

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Copper and Copper Complexes in Tumor Therapy

Wang,

Tang,

Yuan

et al. 2024

ChemMedChem

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Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement in cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential for maintaining copper homeostasis, as imbalances can lead to toxicity and cell death. The development of drugs that target copper homeostasis has emerged as a promising strategy for anticancer treatment, with a particular focus on copper chelators, copper ionophores, and novel copper complexes. Recent research has also investigated the potential of copper complexes in cancer therapy.

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Section: The Pharmacological Effects Of Copper Complexesmentioning

confidence: 99%

Section: The Pharmacological Effects Of Copper Complexesmentioning

confidence: 99%

Copper and Copper Complexes in Tumor Therapy

Wang,

Tang,

Yuan

et al. 2024

ChemMedChem

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“…Utilizing different metals in cancer therapy can potentially affect tumor cells differently and induce distinct molecular pathways compared to platinum-based drugs. Non-platinum-based compounds, including titanium, ruthenium, tin, palladium, and gold complexes, are in focus as potential anticancer agents [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Ludwig,

Ranđelović,

Dimić

et al. 2024

Biomolecules

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The (pentamethylcyclopentadienyl)chloridoiridium(III) complex bearing a κP,κS-bonded Ph2PCH2CH2SPh ligand ([Ir(η5-C5Me5)Cl(Ph2P(CH2)2SPh-κP,κS)]PF6, (1)] was synthesized and characterized. Multinuclear (1H, 13C and 31P) NMR spectroscopy was employed for the determination of the structure. Moreover, SC-XRD confirmed the proposed structure belongs to the “piano stool” type. The Hirshfeld surface analysis outlined the most important intermolecular interactions in the structure. The crystallographic structure was optimized at the B3LYP-D3BJ/6-311++G(d,p)(H,C,P,S,Cl)/LanL2DZ(Ir) level of theory. The applicability of this level was verified through a comparison of experimental and theoretical bond lengths and angles, and 1H and 13C NMR chemical shifts. The Natural Bond Orbital theory was used to identify and quantify the intramolecular stabilization interactions, especially those between donor atoms and Ir(III) ions. Complex 1 was tested on antitumor activity against five human tumor cell lines: MCF-7 breast adenocarcinoma, SW480 colon adenocarcinoma, 518A2 melanoma, 8505C human thyroid carcinoma and A253 submandibular carcinoma. Complex 1 showed superior antitumor activity against cisplatin-resistant MCF-7, SW480 and 8505C cell lines. The mechanism of tumoricidal action on 8505C cells indicates the involvement of caspase-induced apoptosis, accompanied by a considerable reduction in ROS/RNS and proliferation potential of treated cells.

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“…Most traditional anticancer chemotherapeutic agents (organic and metal-based) suffer from the challenges of severe toxicity to different organs, 10,11 inherent resistance 12,13 and poor pharmacokinetic response in vivo, 14 which result in the failure of these drug entities in R&D, clinical trials and further translation to clinical settings. Another major stake for the treatment of cancers is 'metastasis', where the cancer cells migrate to distant or neighboring tissues through blood or lymph, 15,16 resulting in secondary cancers, which are difficult to treat owing to drug resistance issues.…”

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confidence: 99%