Advances in Acute Myeloid Leukemia Stem Cells

Abstract

As a common hematological malignant tumor, acute leukemia is believed to originate from a subpopulation of special cancer cells, named cancer stem cells. Cancer stem cells are recognized to be the main source of tumor origin, multidrug resistance, metastasis, and recurrence. Leukemic stem cells (LSCs) were first identified and confirmed to play an important role in the occurrence and development of leukemia. In this article, we summarize the following content: special markers and sorting methods for acute myeloid leukemia stem cells and the role of cancer stem cells in treatment resistance, metastasis and invasion, recurrence, and target treatment of acute leukemia.

A general view of CD33+leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy

“…Since LSCs were first found in AML in 1997, a wide range of studies have been conducted to characterize and identify populations of different cells in various tissues [19]. LSCs are typically considered to be populations of cells that are capable of proliferation, differentiation, and self-renewal, and that play a significant role in the occurrence of leukemia [20]. Generally, LSCs do not have to arise from a normal stem cell, and the cell origin for most LSCs has not yet been determined [21].…”