Advances in acne clinical research: a new class of topical treatment for moderate-to-severe facial acne

Dessinioti, Clio

doi:10.1111/bjd.21711

Cited by 1 publication

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“…It is considered one of the most common skin disorders, with a lifetime incidence approaching 100% (Collier et al., 2008 ; Thiboutot, 2008 ). The pathogenesis of acne involves four primary mechanisms, including the colonization of Cutibacterium acnes (once known as Propionibacterium acnes ) (Dekio et al., 2019 ), follicular hyperkeratinization, heightened sebum production, and inflammation (Dessinioti, 2022 ). These mechanisms are believed to contribute to the development of the disease, along with interactions involving factors such as genetic susceptibility, medication use, diet, occupation, pollution, climate, lifestyle, hormonal influences, and the immune system (Cong et al., 2019 ; Dréno et al., 2018 ; Gollnick, 2015 ; Kircik, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Oily fish reduces the risk of acne by lowering fasting insulin levels: A Mendelian randomization study

Cheng,

Yu,

Liu

et al. 2024

Food Science & Nutrition

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Meat intake, particularly from oily fish, has been associated with various chronic diseases. However, its relationship with acne has always been controversial. Therefore, we have adopted Mendelian randomization (MR) analysis to investigate the causal relationship between different types of meat intake and acne. The exposure and outcome datasets for this study were obtained from the Integrative Epidemiology Unit (IEU) Open GWAS project. Seven datasets on meat intake were included, which consisted of non‐oily fish, oily fish, lamb/mutton, poultry, pork, beef, and processed meat. The main methods used for MR analysis were inverse variance weighted, weighted median, and MR‐egger. To ensure the accuracy of the results, heterogeneity, pleiotropy, and Mendelian randomization pleiotropy residual sum and outlier (MR‐PRESSO) analyses were conducted. Additionally, an analysis of four risk factors (fasting insulin, insulin resistance, total testosterone level, and estradiol level) was performed to investigate the underlying mechanisms linking statistically significant meat intake to acne. Oily fish intake was found to be a protective factor for acne (OR: 0.22, 95% CI: 0.10–0.49, p < .001), and it was also observed that oily fish intake can reduce the level of fasting insulin by the IVW method (OR: 0.89, 95% CI: 0.81–0.98, p = .02). No causal relationship was identified between other types of meat intake and acne. The intake of oily fish reduces the risk of acne by lowering fasting insulin levels.

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Section: Introductionmentioning

confidence: 99%

Oily fish reduces the risk of acne by lowering fasting insulin levels: A Mendelian randomization study

Cheng,

Yu,

Liu

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Advances in acne clinical research: a new class of topical treatment for moderate-to-severe facial acne

Abstract: Lisa J. Gould: Conceptualization (equal); writingoriginal draft (equal); writingreview and editing (equal). Elizabeth White-Chu: Writingreview and editing (equal).

Cited by 1 publication

References 10 publications

Oily fish reduces the risk of acne by lowering fasting insulin levels: A Mendelian randomization study

Oily fish reduces the risk of acne by lowering fasting insulin levels: A Mendelian randomization study

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