Advances for pharmacological activities of
            <i>Polygonum cuspidatum</i>
            - A review

Ke, Jia; Li, Meng-Ting; Shou, Xu; Ma, Jianpeng; Liu, Mingyuan; Yan, Han

doi:10.1080/13880209.2022.2158349

Cited by 18 publications

(12 citation statements)

References 86 publications

(91 reference statements)

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“…They found that crude extract obtained from the leaves of Brucea antidysenterica induces cell death mediated by caspases on drug-resistant cancer cells, such as CCRF-CEM, a human leukemia cell line, at a low concentration (from 12.42 µg mL −1 to 38.70 µg mL −1 ). Other authors reported that ethanol extracts of P. cuspidatum demonstrated efficacy on the loss of viability of cells in oral, breast, and ovarian cancer at lower concentrations, EC 50 : <50 µg mL −1 [ 17 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Biological Properties of an Optimized Extract of Polygonum cuspidatum Using Ultrasonic-Assisted Extraction

et al. 2023

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Phytochemicals are natural compounds found in plants that have potential health benefits such as antioxidants, anti-inflammatory and anti-cancer properties, and immune reinforcement. Polygonum cuspidatum Sieb. et Zucc. is a source rich in resveratrol, traditionally consumed as an infusion. In this study, P. cuspidatum root extraction conditions were optimized to increase antioxidant capacity (DPPH, ABTS+), extraction yield, resveratrol concentration, and total polyphenolic compounds (TPC) via ultrasonic-assisted extraction using a Box–Behnken design (BBD). The biological activities of the optimized extract and the infusion were compared. The optimized extract was obtained using a solvent/root powder ratio of 4, 60% ethanol concentration, and 60% ultrasonic power. The optimized extract showed higher biological activities than the infusion. The optimized extract contained 16.6 mg mL−1 resveratrol, high antioxidant activities (135.1 µg TE mL−1 for DPPH, and 230.4 µg TE mL−1 for ABTS+), TPC (33.2 mg GAE mL−1), and extraction yield of 12.4%. The EC50 value (effective concentration 50) of the optimized extract was 0.194 µg mL−1, which revealed high cytotoxic activity against the Caco-2 cell line. The optimized extract could be used to develop functional beverages with high antioxidant capacity, antioxidants for edible oils, functional foods, and cosmetics.

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Section: Discussionmentioning

confidence: 99%

“…Emodin is an anthraquinone located in the rhizome, and quercetin is a flavonoid in leaves and stems. Polyphenols are commonly found in flowers [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Biological Properties of an Optimized Extract of Polygonum cuspidatum Using Ultrasonic-Assisted Extraction

et al. 2023

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“…Polygonum cuspidatum has the ability to clear heat and detoxify the body and is commonly used to treat lungheating coughs. [8][9][10][11] In the COVID-19 epidemic, P cuspidatum was widely used and its use was recognized by the Chinese medicine community. [11,12] Modern pharmacological studies have shown that the various active ingredients in P cuspidatum mainly include anthraquinones, flavonoids, phenols and other compounds, which have antibacterial, antiviral, antioxidant and microcirculatory improving effects.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] In the COVID-19 epidemic, P cuspidatum was widely used and its use was recognized by the Chinese medicine community. [11,12] Modern pharmacological studies have shown that the various active ingredients in P cuspidatum mainly include anthraquinones, flavonoids, phenols and other compounds, which have antibacterial, antiviral, antioxidant and microcirculatory improving effects. [13][14][15][16] However, the specific mechanism of action by which P cuspidatum exerts its value during epidemics is unclear.…”

Section: Introductionmentioning

confidence: 99%

Preliminary study on molecular mechanism of COVID-19 intervention by Polygonum cuspidatum through computer bioinformatics

Liu,

Han,

Yan

2024

Medicine

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To explore the mechanism of action of Polygonum cuspidatum in intervening in coronavirus disease 2019 using a network pharmacology approach and to preliminarily elucidate its mechanism. The active ingredients and action targets of P cuspidatum were classified and summarized using computer virtual technology and molecular informatics methods. The active ingredients and relevant target information of P cuspidatum were identified using the TCM Systematic Pharmacology Database and Analysis Platform, the TCM Integrated Pharmacology Research Platform v2.0, and the SwissTarget database. The GENECARDS database was used to search for COVID-19 targets. The STRING database was analyzed and combined with Cytoscape 3.7.1 software to construct a protein interaction network map to screen the core targets. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was then performed. The core compound, polydatin, was selected and the core targets were analyzed by computer virtual docking using software such as discovery studio autodock tool. In vitro cell models were constructed to experimentally validate the activity of the core compound, polydatin. By computer screening, we identified 9 active ingredients and their corresponding 286 targets from P cuspidatum. A search of the GENECARDS database for COVID-19 yielded 303 core targets. By mapping the active ingredient targets to the disease targets, 27 overlapping targets could be extracted as potential targets for the treatment of COVID-19 with P cuspidatum. In addition, the enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathway on core targets showed that the coronavirus disease, MAPK signaling pathway, NF kappa B signaling pathway, and other signaling pathways were highly enriched. Combined with the degree-high target analysis in the protein interaction network, it was found to be mainly concentrated in the NF-kappaB (NF-κB) signaling pathway, indicating that the NF-κB signaling pathway may be an important pathway for P cuspidatum intervention. In vitro assays showed no effect of 0.1 to 10 μM polydatin on cell viability, but an inhibitory effect on the transcriptional activity of NF-κB-RE. Molecular docking showed stable covalent bonding of polydatin molecules with Il-1β protein at residue leu-26, TNF protein ser-60, residue gly-121, and residue ile-258 of ICAM-1 protein, indicating a stable docking result. The treatment of COVID-19 with P cuspidatum is characterized by multi-component, multi-target, and multi-pathway, which can exert a complex network of regulatory effects through the interaction between different targets, providing a new idea and basis for further exploration of the mechanism of action of P cuspidatum in the treatment of COVID-19.

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“…Polygonum cuspidatum (Pc) primarily comprises polydatin, resveratrol, emodin, quercetin, and their derivatives as principal bioactive phytochemical components. The therapeutic and preventive effects of Pc against various human diseases have been extensively investigated [ 1 ]. The anti-inflammatory, antioxidant, antiviral, and antimicrobial properties of Pc have been validated in cultured cell lines and animal models [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions

Kim,

Han,

Lim

et al. 2024

Nutrients

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Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. Polygonum cuspidatum (Pc) contains flavonoids, anthraquinones, and stilbenes, imparting protective effects against inflammatory diseases, cancer, diabetes, and cardiovascular diseases. However, the effects of fermented Pc on skeletal muscle strength remain unexplored. In this study, we generated fermented Pc using a complex of microorganisms containing Lactobacillus spp. (McPc) and assessed its effects on muscle strength and motor function in mice. Compared to unfermented Pc water extract, elevated levels of emodin and resveratrol were noted in McPc. This was identified and quantified using UPLC-QTOF/MS and HPLC techniques. Gene expression profiling through RNA-seq and quantitative RT-PCR revealed that McPc administration upregulated the expression of genes associated with antioxidants, glycolysis, oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis in cultured C2C12 myotubes and the gastrocnemius muscle in mice. McPc significantly improved skeletal muscle strength, motor coordination, and traction force in mice subjected to sciatic neurectomy and high-fat diet (HFD). McPc administration exhibited more pronounced improvement of obesity, hyperglycemia, fatty liver, and hyperlipidemia in HFD mice compared to control group. These findings support the notion that emodin and resveratrol-enriched McPc may offer health benefits for addressing skeletal muscle weakness.

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Advances for pharmacological activities of Polygonum cuspidatum - A review

Cited by 18 publications

References 86 publications

Evaluation of the Biological Properties of an Optimized Extract of Polygonum cuspidatum Using Ultrasonic-Assisted Extraction

Evaluation of the Biological Properties of an Optimized Extract of Polygonum cuspidatum Using Ultrasonic-Assisted Extraction

Preliminary study on molecular mechanism of COVID-19 intervention by Polygonum cuspidatum through computer bioinformatics

Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions

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