Advances for improved diagnosis of microscopic colitis in patients with chronic diarrhoea

Zabana, Yamile; Ferrer, Carme; Aceituno, Montserrat; Salas, Antonio; Fernández‐Bañares, Fernando

doi:10.1016/j.gastre.2016.01.008

Cited by 4 publications

(3 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…217 The most characteristic feature of LC is an increased number of IELs in the surface epithelium !20 per 100 epithelial cells. 1,3,4,7,[233][234][235][236][237][238][239][240][241][242][243][244] Counting should be performed in the surface epithelium, and areas in close relation to lymphoid aggregates in the lamina propria should be avoided. 1 Focal and mild damage of the surface epithelium, including flattening, mucin depletion and vacuolisation, is seen, although not as prominently as in CC.…”

Section: Diagnosis Of MC What Is the Endoscopic Appearance Of Mc?mentioning

confidence: 99%

“…221,236,241,250,252 Supplementary immunohistochemical staining might be helpful, especially in borderline cases, since highlighting the lymphocytes makes counting easier. 1,3,6,244,257 This might lead to over diagnosing and it has been suggested to use higher cut-off values when counting is performed on CD3-stained slides. 258 What are the criteria for the histological diagnosis of MCi?…”

Section: Diagnosis Of MC What Is the Endoscopic Appearance Of Mc?mentioning

confidence: 99%

See 1 more Smart Citation

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, non-bloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder. Methods Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the certainty of the evidence. Statements and recommendations were developed by working groups consisting of gastroenterologists, pathologists and basic scientists, and voted upon using the Delphi method. Results These guidelines provide information on epidemiology and risk factors of microscopic colitis, as well as evidence-based statements and recommendations on diagnostic criteria and treatment options, including oral budesonide, bile acid binders, immunomodulators and biologics. Recommendations on the clinical management of microscopic colitis are provided based on evidence, expert opinion and best clinical practice. Conclusion These guidelines may support clinicians worldwide to improve the clinical management of patients with microscopic colitis.

show abstract

Section: Diagnosis Of MC What Is the Endoscopic Appearance Of Mc?mentioning

confidence: 99%

Section: Diagnosis Of MC What Is the Endoscopic Appearance Of Mc?mentioning

confidence: 99%

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Age increases the risk of MC with an estimated 8.3 times more by age >65 years compared to <65 years. The incidence is higher in women than in men, with a female-male incidence ratio of 3.05 for CC and 1.92 for LC [8].…”

Section: Discussionmentioning

confidence: 96%

Collagenous Colitis with Endoscopic Manifestations: About a Clinical Case

Héctor¹,

Hernandez²,

Sasplugas³

2021

Act Sci wom hea

View full text Add to dashboard Cite

<p>Management of microscopic colitis: challenges and solutions</p>

Shor¹,

Churrango²,

Hosseini³

et al. 2019

CEG

View full text Add to dashboard Cite

Microscopic colitis (MC) is a chronic inflammatory bowel disease characterized by nonbloody diarrhea in the setting of normal appearing colonic mucosa. MC has two main subtypes based on histopathologic features, collagenous colitis and lymphocytic colitis. Management of both subtypes is the same, with treatment goal of reducing the number of bowel movements and improving consistency. First-line treatment involves counseling the patient about decreasing their risk factors, like discontinuing smoking and avoiding medications with suspected association such as NSAIDs, proton pump inhibitor, ranitidine, and sertraline. Starting loperamide for immediate symptomatic relief is used as an adjunct to therapy with glucocorticoids. Budesonide is considered first-line treatment for MC given its favorable side effect profile and good efficacy, though relapse rates are high. Systemic glucocorticoids should be reserved to patients unable to take budesonide. In glucocorticoid refractory disease, medications that have been tried include cholestyramine, bismuth salicylate, antibiotics, probiotics, aminosalicylates, immunomodulators, and anti-tumor necrosis factor-alpha inhibitors. More research is needed for the creation of a systematic stepwise approach for relapsing and refractory disease.

show abstract

Advances for improved diagnosis of microscopic colitis in patients with chronic diarrhoea

Cited by 4 publications

References 97 publications

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

Collagenous Colitis with Endoscopic Manifestations: About a Clinical Case

<p>Management of microscopic colitis: challenges and solutions</p>

Contact Info

Product

Resources

About