Advances and Problems in Preclinical Models for Childhood Cancer

Abstract

Microblogging today has gotten an acclaimed specific instrument amongNeuroblastoma is a sympathetic nervous system disease in children and is themost prevalent solid tumor in childhood, accounting for 15% of all pediatriconcology deaths. Nearly 80% of patients with this clinically active condition donot react to current treatments in the long run. The precise portrayal of tumorbiology and diversity is the key obstacle in the discovery and evaluation ofnovel agents for pediatric drug growth. In addition to this restriction, the lowprevalence of neuroblastoma renders it difficult to enroll qualifying patientsfor early phase clinical trials, emphasizing the importance of thoroughpreclinical studies to ensure that the right drugs are chosen. To address theseissues, researchers need new preclinical models, technologies, and principles.Tissue engineering provides appealing methods for developing threedimensional(3D) cell models utilizing different biomaterials andmanufacturing techniques that replicate the geometry, dynamics,heterogeneity, metabolic gradients, and cell connectivity of the native tumormicroenvironment. We address existing laboratory models and evaluate theirability to reflect the systemic organization and physiological conditions of thehuman body, as well as current and emerging strategies to recapitulate thetumor niche utilizing tissue-engineered platforms in this study. Finally, we'lltalk about how innovative 3Din vitroculture systems might be used to answerunanswered questions in neuroblastoma biology.