Advances and Perspectives in Relation to the Molecular Basis of Diabetic Retinopathy—A Review

Błaszkiewicz, Michał; Walulik, Agata; Florek, Kamila; Górecki, Ignacy; Sławatyniec, Olga; Gomułka, Krzysztof

doi:10.3390/biomedicines11112951

Cited by 3 publications

(3 citation statements)

References 165 publications

(202 reference statements)

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“…Moreover, AGEs cause pathological alterations, including protein cross-linking and endoplasmic reticulum (ER) stress, worsening retinal cell dysfunction and blood-retinal barrier degradation. The authors underscore SAF's role in early DR detection and agree with previous studies on its efficacy as a non-invasive marker, suggesting that non-invasively measuring AGE accumulation offers a more accurate reflection of AGE levels than analyzing serum concentrations, which may not accurately represent tissue AGE levels and varies with the molecules' half-life [46].…”

Section: Saf and Microvascular Complications Of Dm (Neuropathy Retino...supporting

confidence: 80%

Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes

Reurean-Pintilei,

Pantea Stoian,

Salmen

et al. 2024

Biomedicines

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Advanced Glycation End Products (AGEs) contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) and cardiovascular (CV) diseases (CVDs), making their non-invasive assessment through skin autofluorescence (SAF) increasingly important. This study aims to investigate the relationship between SAF levels, cardiovascular risk, and diabetic complications in T2DM patients. We conducted a single-center, cross-sectional study at Consultmed Hospital in Iasi, Romania, including 885 T2DM patients. The assessment of SAF levels was performed with the AGE Reader™, (Diagnoptics, Groningen, The Netherlands). CVD prevalence was 13.9%, and according to CV risk category distribution, 6.1% fell into the moderate-risk, 1.13% into the high-risk, and 92.77% into the very-high-risk category. The duration of DM averaged 9.0 ± 4.4 years and the mean HbA1c was 7.1% ± 1.3. After adjusting for age and eGFR, HbA1c values showed a correlation with SAF levels in the multivariate regression model, where a 1 SD increase in HbA1c was associated with a 0.105 SD increase in SAF levels (Nagelkerke R2 = 0.110; p < 0.001). For predicting very high risk with an SAF cut-off of 2.35, sensitivity was 67.7% and specificity was 56.2%, with an AUC of 0.634 (95% CI 0.560–0.709, p = 0.001). In T2DM, elevated SAF levels were associated with higher CV risk and HbA1c values, with 2.35 identified as the optimal SAF cut-off for very high CV risk.

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Section: Saf and Microvascular Complications Of Dm (Neuropathy Retino...supporting

confidence: 80%

Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes

Reurean-Pintilei,

Pantea Stoian,

Salmen

et al. 2024

Biomedicines

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“…Previously, the relationships between miR and diabetic retinopathy [17,18], oxygeninduced retinopathy [19], Müller glial cell function [20,21], light adaptation [22], and so on have been reported. Although α-Melanocyte-stimulating hormone was reported to reduce the excitotoxicity of chicken retinal neurons via the downregulation of miR-194 [23], little information has been shown about the relationship between miR and excitotoxicity of the mammalian retinal neuron.…”

Section: Discussionmentioning

confidence: 99%

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

Sone,

Mori,

Sakamoto

et al. 2024

IJMS

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Glaucoma is one of the leading causes of acquired blindness and characterized by retinal ganglion cell (RGC) death. MicroRNAs are small noncoding RNAs that degrade their target mRNAs. Apoptosis is one of the common mechanisms leading to neuronal death in many neurodegenerative diseases, including glaucoma. In the present study, we identified microRNAs that modulate RGC death caused by the intravitreal injection of N-methyl-d-aspartic acid (NMDA). We found an upregulation of miR-29b and downregulation of miR-124 in the retina of the NMDA-injected eyes. The intravitreal injection of an miR-29b inhibitor 18 h before NMDA injection reduced RGC death and the downregulation of myeloid cell leukemia 1 (MCL-1), an anti-apoptotic factor, induced by intravitreal NMDA. The intravitreal injection of an miR-124 mimic 18 h before NMDA injection also reduced RGC death and the upregulation of B-cell/chronic lymphocytic leukemia lymphoma 2 (bcl-2)-associated X protein (Bax) and bcl-2 interacting protein (Bim), pro-apoptotic factors, induced by intravitreal NMDA. These data suggest that expressional changes in microRNA are involved in the excitotoxicity of RGCs, and that complement and/or inhibition of microRNA may be a potential therapeutic approach for the diseases related to the excitotoxicity of RGCs, such as glaucoma and retinal central artery occlusion.

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“…Therefore, providing effective extended care is crucial to enhance home care effectiveness and improve treatment and rehabilitation levels. [8,9]…”

Section: Introductionmentioning

confidence: 99%

Influence of continuous 4C nursing on quality of life and self-care ability of patients with diabetes retinopathy: An observational study

Wufuer,

Ma,

Ainiwa

et al. 2024

Medicine

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This study aims to investigate the impact of continuous 4C nursing on patients with diabetes retinopathy (DR) and its influence on self-care ability. A total of 100 DR patients admitted to our hospital from October 2020 to October 2022 were randomly divided into a control group and an observation group, with 50 cases in each group. The control group received routine care, while the observation group received continuous 4C care. The nursing effects of both groups were compared. After nursing, the observation group showed a lower self-rating anxiety scale score and a higher self-care ability scale score compared to the control group (P < .05). The SQQL-VI scores for all social activities were also higher in the observation group (P < .05). Additionally, the observation group had lower levels of fasting blood glucose, 2-hour postprandial blood glucose, and glycated hemoglobin than the control group (P < .05). Moreover, the observation group had higher visual acuity and lower intraocular pressure than the control group (P < .05). The visual impairment rate was lower and the overall compliance rate was higher in the observation group compared to the control group (P < .05). After nursing, both groups showed improvements in symptoms, visual function, physical function, psychological and social activity scores, visual acuity, and patient satisfaction scores. The observation group showed greater improvements compared to the control group (P < .05). The application of continuous 4C nursing in DR patients has shown positive effects, including improved patient compliance and satisfaction, enhanced patient quality of life and visual acuity. These findings suggest that continuous 4C nursing should be widely promoted and applied in clinical practice.

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Advances and Perspectives in Relation to the Molecular Basis of Diabetic Retinopathy—A Review

Cited by 3 publications

References 165 publications

Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes

Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes

The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina

Influence of continuous 4C nursing on quality of life and self-care ability of patients with diabetes retinopathy: An observational study

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