Advances and challenges in portable optical biosensors for onsite detection and point-of-care diagnostics

Rasheed, Sufian; Kanwal, Tehreem; Ahmad, Naseer; Fatima, Batool; Najam-ul-Haq, Muhammad; Hussain, Dilshad

doi:10.1016/j.trac.2024.117640

Cited by 17 publications

(6 citation statements)

References 190 publications

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“…The system usability is enhanced by a magnet-guided snapping mechanism that positions the sensor chips opposite the optical sensor head. This feature is instrumental in facilitating the potential application of the sensor system in portable or wearable biosensing devices [32,33]. The straightforward manual insertion and magnetic fixation process, combined with the system tolerance for operation by individuals without specialized training, suggests its suitability for point-of-care scenarios.…”

Section: Discussionmentioning

confidence: 99%

Repeatable Passive Fiber Optic Coupling of Single-Mode Waveguides in High-Precision Disposable Photonic Biosensors

Reck,

von Emden,

Mihov

et al. 2024

Photonics

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This research demonstrates a method for the repeatable passive fiber optic coupling of single-mode waveguides with a micron-scale accuracy for high-precision disposables. The aim is to broaden the application of photonic integrated circuits (PICs) from traditional fiber optic communication systems to include medical, life science, and environmental sensing applications. The proposed passive coupling system enables the straightforward and reliable interchange of disposable photonic chips without manual read-out unit adjustments. Robustness is attributed to the chip-side grating couplers with 3 dB coupling tolerances exceeding ± 25 µm and a mechanical three-groove kinematic method ensuring precise alignment. The system simplicity is highlighted by the simple manual insertion and fixation of silicon nitride (Si3N4) PICs on a carrier using magnetic force and passive alignment features. Testing on a batch of 99 identical yet independent units revealed a standard deviation (SD) of 5.1 dB in coupling loss, without realignment post-calibration. This eliminates the need for active alignment processes, showing its potential for enabling field use. A usability assessment with five untrained operators confirms the suitability for various end-users, with consistent performance in engaging and disengaging disposable PICs. The research significantly advances the integration of photonic sensor technology into practical applications, particularly for chemical and biological fluid analysis in point-of-care settings.

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Section: Discussionmentioning

confidence: 99%

Repeatable Passive Fiber Optic Coupling of Single-Mode Waveguides in High-Precision Disposable Photonic Biosensors

Reck,

von Emden,

Mihov

et al. 2024

Photonics

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“…Additionally, the combination of microfluidics , and, importantly, the most recent developments in flexible and stretchable optical sensors have opened pathways to new functionalities and have become the most useable POC devices. The emphasis on POC devices for biosensing in healthcare and diagnostics has developed significantly in the last few decades . One of the most challenging parts of developing POC devices is reducing the size without affecting the device’s performance.…”

Section: Developments and Future Perspectivesmentioning

confidence: 99%

“…The emphasis on POC devices for biosensing in healthcare and diagnostics has developed significantly in the last few decades. 193 One of the most challenging parts of developing POC devices is reducing the size without affecting the device’s performance. Another one is the trade-off between the cost with respect to the detection accuracy of the POC biosensing devices.…”

Section: Developments and Future Perspectivesmentioning

confidence: 99%

Advancements and Perspectives in Optical Biosensors

Mostufa,

Rezaei,

Ciannella

et al. 2024

ACS Omega

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Optical biosensors exhibit immense potential, offering extraordinary possibilities for biosensing due to their high sensitivity, reusability, and ultrafast sensing capabilities. This review provides a concise overview of optical biosensors, encompassing various platforms, operational mechanisms, and underlying physics, and it summarizes recent advancements in the field. Special attention is given to plasmonic biosensors and metasurface-based biosensors, emphasizing their significant performance in bioassays and, thus, their increasing attraction in biosensing research, positioning them as excellent candidates for lab-on-chip and point-of-care devices. For plasmonic biosensors, we emphasize surface plasmon resonance (SPR) and its subcategories, along with localized surface plasmon resonance (LSPR) devices and surface enhance Raman spectroscopy (SERS), highlighting their ability to perform diverse bioassays. Additionally, we discuss recently emerged metasurface-based biosensors. Toward the conclusion of this review, we address current challenges, opportunities, and prospects in optical biosensing. Considering the advancements and advantages presented by optical biosensors, it is foreseeable that they will become a robust and widespread platform for early disease diagnostics.

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“…For point-of-care patient management, novel biosensor detection technologies may be compacted. 221 This section will investigate novel PSA detection methods based on biotinylated NPs. A novel form of portable biodevice with a sandwich structure and high sensitivity has been developed to detect PSA.…”

Section: Biotin-functionalized Nps For Cancer Detectionmentioning

confidence: 99%

Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection

Fathi-karkan,

Sargazi,

Shojaei

et al. 2024

Nanoscale

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Advances and challenges in portable optical biosensors for onsite detection and point-of-care diagnostics

Cited by 17 publications

References 190 publications

Repeatable Passive Fiber Optic Coupling of Single-Mode Waveguides in High-Precision Disposable Photonic Biosensors

Repeatable Passive Fiber Optic Coupling of Single-Mode Waveguides in High-Precision Disposable Photonic Biosensors

Advancements and Perspectives in Optical Biosensors

Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection

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