Advancements of compounds targeting Wnt and Notch signalling pathways in the treatment of inflammatory bowel disease and colon cancer

Pu, Zhuonan; Yang, Fang; Wang, Liang; Diao, Yun-Peng; Chen, Dapeng

doi:10.1080/1061186x.2020.1864741

Cited by 18 publications

(20 citation statements)

References 137 publications

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“…Many cell lineages are vital for maintenance of intestinal epithelial barrier integrity, which arise by differentiation and proliferation of intestinal stem cells (ISCs) ( 27 ). Crypt-based stem cells, which are near the base of the crypts, need to actively proliferate to maintain continuous renewal of different cell lineages ( 28 ).…”

Section: Importance Of Proliferation Pathways In Intestinementioning

confidence: 99%

“…Multiple signaling pathways, such as Hippo, Notch, and Wnt, are responsible for regulating the proliferation and the differentiation in intestinal epithelial cells ( 9 – 13 , 31 ). Finally, an imbalance among these types of pathways in epithelium could lead to colorectal cancer and IBD ( 27 ).…”

Section: Importance Of Proliferation Pathways In Intestinementioning

confidence: 99%

“…The Wnt signaling pathways are a group of signaling pathways, which commence with proteins that transmit signals into a cell by cell surface receptors ( 32 , 33 ). Therefore, this pathway is activated by the cell–cell communications and it has been conserved throughout the biological evolution ( 27 ). Wnt pathway is divided into β-catenin dependent (canonical) and β-catenin independent (noncanonical) types ( 34 ).…”

Section: Wnt Pathwaymentioning

confidence: 99%

Section: Notch Pathwaymentioning

confidence: 99%

“…The Notch signaling pathway is conserved during the evolution that is presented in most animals ( 27 ). It regulates the differentiation and development of cells, tissues, and organs by interactions among nearby cells ( 27 ). The pathway consists of receptors, ligands, transformation complexes, and several regulatory molecules ( 64 ).…”

Section: Notch Pathwaymentioning

confidence: 99%

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Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs)

et al. 2022

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Inflammatory bowel disease (IBD) is a disorder, which involves the gastrointestinal (GI) tract consisting Crohn's disease (CD) and ulcerative colitis (UC). The etiology of this disease is not yet clear and, hence, there are numerous medications and treatments for patients with IBD, although a definite and permanent treatment is still missing. Therefore, finding novel therapeutic approaches are vital for curing patients with IBD. In the GI tract, there are various lineages of cells with different roles that their existence is necessary for the barrier function of intestinal epithelial cells (IECs). Therefore, signaling pathways, which manage the hemostasis of cell lineages in intestine, such as Wnt, Notch, and Hippo, could have crucial roles in regulation of barrier function in the intestine. Additionally, these signaling pathways function as a governor of cell growth, tissue homeostasis, and organ size. In patients with IBD, recent studies have revealed that these signaling pathways are dysregulated that it could result in depletion or excess of a cell lineage in the intestine. Moreover, dysregulation of these signaling pathways in different cell lineages of the immune system could lead to dysregulation of the immune system's responses in IBD. In this article, we summarized the components and signaling of Wnt, Notch, and Hippo pathways and their role in the intestine and immune system. Furthermore, we reviewed latest scientific literature on the crosstalk among these three signaling pathways in IBD. An overview of these three signaling pathways and their interactions in IBD could provide a novel insight for prospective study directions into finding efficient medications or treatments.

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Section: Importance Of Proliferation Pathways In Intestinementioning

confidence: 99%

Section: Importance Of Proliferation Pathways In Intestinementioning

confidence: 99%

Section: Wnt Pathwaymentioning

confidence: 99%

Section: Notch Pathwaymentioning

confidence: 99%

Section: Notch Pathwaymentioning

confidence: 99%

See 3 more Smart Citations

Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs)

et al. 2022

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Human Mucosal Organ and Application of Probiotics

Mohanty¹,

Gurjar²,

Nagarajan³

2022

Prebiotics and Probiotics in Disease Regulation and Management

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Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects

Hussain

Islam

Khan

et al. 2021

Phytotherapy Research

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The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy, radiation, and surgery are the most common therapeutic strategies for treatment, with chemotherapy being the most successful. Nonetheless, these treatments exhibit poor effectiveness due to toxicity and resistance. Therefore, combination therapies of natural products may be used as an effective and novel strategy to overcome such barriers. Cisplatin is a platinum‐based chemotherapy agent, and when administered alone, it can lead to severe adverse effects and resistance mechanism resulting in therapeutic failure. Curcumin is a polyphenolic compound extracted from turmeric (Curcuma longa) exhibiting anticancer potential with minimal adverse effects. The combination therapy of curcumin and cisplatin is a novel strategy to mitigate/attenuate cisplatin‐related adverse effects and improve the barrier of resistance reducing unwanted effects. However, there are uncertainties on the efficacy of curcumin, and more in depth and high‐quality studies are needed. This review aims to explain the adverse effects related to individual cisplatin delivery, the positive outcome of individual curcumin delivery, and the combination therapy of curcumin and cisplatin from nano platform as a novel strategy for cancer therapy.

show abstract

Advancements of compounds targeting Wnt and Notch signalling pathways in the treatment of inflammatory bowel disease and colon cancer

Cited by 18 publications

References 137 publications

Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs)

Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs)

Human Mucosal Organ and Application of Probiotics

Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects

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