Advancements in the synergy of isothermal amplification and CRISPR-cas technologies for pathogen detection
Xiaolei Mao,
Minghui Xu,
Shuyin Luo
et al.
Abstract:In the realm of pathogen detection, isothermal amplification technology has emerged as a swift, precise, and sensitive alternative to conventional PCR. This paper explores the fundamental principles of recombinase polymerase amplification (RPA) and recombinase-aid amplification (RAA) and reviews the current status of integrating the CRISPR-Cas system with RPA/RAA techniques. Furthermore, this paper explores the confluence of isothermal amplification and CRISPR-Cas technology, providing a comprehensive review a… Show more
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