Advancements in the Research of Therapeutic Mechanisms of Kidney-Nourishing Approach for Premature Ovarian Failure

Abstract

Premature ovarian failure (POF) is a prevalent condition that significantly impairs the quality of life for women during their reproductive years. Its implications for patients and their daily routines are profound, and the disease's chronic progression can even trigger a range of other systemic ailments. In recent years, numerous studies have highlighted the reduced toxicity and side effects of Traditional Chinese Medicine (TCM) in treating POF, along with its notable therapeutic effects. TCM holds that the kidney governs reproduction, and a robust kidney essence leads to strong reproductive function. The kidney-produced "Tiangui" directly oversees menstruation. As such, the approach of nourishing the kidney and regulating menstruation in treating POF is grounded in solid theory and rich practical experience. This paper, from the perspective of kidney nourishment in TCM, reviews relevant research both domestically and internationally on how TCM's kidney-nourishing prescriptions improve POF. It also summarizes the mechanisms involved, aiming to provide valuable insights for clinical efficacy and treatment strategies for POF.