Advancements in the Application of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs)
Sang-Woo Han,
Hyung-Sik Won
Abstract:Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a significant potential for novel therapeutic applications because of their bioactive properties, stability, and specificity. RiPPs are synthesized on ribosomes, followed by intricate post-translational modifications (PTMs), crucial for their diverse structures and functions. PTMs, such as cyclization, methylation, and proteolysis, play crucial roles in enhancing RiPP stability and bioactivity. Advances in synthetic biology an… Show more
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