Advancements in nanobody generation: Integrating conventional, in silico, and machine learning approaches
D Jagadeeswara Reddy,
Girijasankar Guntuku,
Mary Sulakshana Palla
Abstract:Nanobodies, derived from camelids and sharks, offer compact, single‐variable heavy‐chain antibodies with diverse biomedical potential. This review explores their generation methods, including display techniques on phages, yeast, or bacteria, and computational methodologies. Integrating experimental and computational approaches enhances understanding of nanobody structure and function. Future trends involve leveraging next‐generation sequencing, machine learning, and artificial intelligence for efficient candid… Show more
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