Advancements in Biomedical Micro/Nano Tools and Technology

Chiou, Eric P. Y.; Tsutsui, Hideaki

doi:10.1177/2211068213505834

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Advances in micro-and nano-fabrication methods have provided new means of fabricating micro-and nano-devices for drug and gene delivery [4][5][6], tissue engineering [7], biosensors [8,9] and diagnostic systems, for proteins [8], DNA microarrays [10] and microfluidic circuits for biochemical sample preparation [11].…”

Section: Introductionmentioning

confidence: 99%

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

Bruce

Samperi

Amabilino

et al. 2021

Porphyrin Science by Women

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The generation of singlet oxygen (SO), primarily by using a combination of light and photosensitizers in the presence of the dissolved gas, finds applications in both chemistry and medicine.The efficiency of its formation can be enhanced by immobilization of the photosensitizers. In this work, we have explored the covalent functionalization in suspension of hexahedral slab-like polysilicon microparticles (P, with a largest dimension of three microns) with a model photosensitizer, 5-(4isothiocyanatophenyl)-10,15,20-(triphenyl)porphyrin (ITC-P), and evaluated the singlet oxygen generation of this photosensitiser in solution and after immobilization (ITC-P-P) in suspension. The SO detection experiment on the functionalised microparticles was performed using a hydrogel as the matrix supporting the microparticles (to avoid their settling), and revealed that ITC-P-P in suspension are capable of generating SO more efficiently than the free ITC-P in solution.

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Section: Introductionmentioning

confidence: 99%

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

Bruce

Samperi

Amabilino

et al. 2021

Porphyrin Science by Women

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“…Micro–nano technologies have broad applications such as controlled drug delivery, photoacoustic imaging, chemotherapy, and biomedical diagnosis . Notably, the micro–nano technology has unique advantages for biomedical diagnosis, because the key components of life fall right into the micro–nano scale: from cells (1–100 µm), to organelles (100 nm to 1 µm), and to proteins, nucleic acids, and other chemicals (1–100 nm), all within the detection range of micro–nano technology …”

Section: Introductionmentioning

confidence: 99%

Micro/Nano Technology for Next‐Generation Diagnostics

Gao

Tang

et al. 2019

Small Methods

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There has been a constant and urgent need to upgrade the current diagnostic technologies to the next generation by utilizing innovative advanced technologies in order to meet new challenges. Micro/nano technology, a series of methods for design and manipulation materials at the micrometer and nanometer scales, which perfectly covers the key building blocks of life including cells, organelles, proteins, nucleic acids, and other components, has unique advantages over current diagnostic methods. For the applications of micro–nano technology in next‐generation diagnostics, three categories, including microchip‐based devices, DNA nanomachines, and DNA nanomaterials, are extensively reviewed. Specifically, for the microchip‐based devices, terahertz technology and surface acoustic wave technology show their ultrasensitivity of label‐free, amplification‐free diagnosis. For the DNA nanomachines, DNA tweezers, DNA robots, and DNA walkers exhibit a great potential for diagnosis with the arbitrary structures and controllable motion behaviors. For the DNA nanomaterials, DNA aptamers, DNAzymes, and hybrid DNA nanomaterials provide sensitive biorecognition elements and versatile signal transductions, which are demonstrated as promising material candidates for the next‐generation diagnostics. Through this review, it is envisioned that micro/nano technologies will play an important role in the next‐generation diagnostics.

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“…Hybrid materials obtained by the combination of micro-and nano-technology are considered as extremely relevant to science and technology, in particular for applications in biomedical science, catalysis and waste treatment [1][2][3]. Advances in micro-and nano-fabrication methods have provided new means of fabricating microand nano-devices for drug and gene delivery [4][5][6], tissue engineering [7], biosensors [8,9] and diagnostic systems, for proteins [8], DNA microarrays [10] and microfluidic circuits for biochemical sample preparation [11].…”

Section: Introductionmentioning

confidence: 99%

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

Bruce

Samperi

Amabilino

et al. 2019

J. Porphyrins Phthalocyanines

View full text Add to dashboard Cite

The generation of singlet oxygen (SO), primarily by using a combination of light and photosensitizers in the presence of a dissolved gas, finds applications in both chemistry and medicine. The efficiency of its formation can be enhanced by immobilization of the photosensitizers. In this work, we have explored the covalent functionalization in suspension of hexahedral slab-like polysilicon microparticles (mP, with a largest dimension of three microns) with a model photosensitizer, 5-(4-isothiocyanatophenyl)-10,15,20-(triphenyl)porphyrin (ITC-P), and evaluated the singlet oxygen generation of this photosensitizer in solution and after immobilization (ITC-P-mP) in suspension. The SO-detection experiment on the functionalized microparticles was performed using a hydrogel as the matrix supporting the microparticles (to avoid their settling), and revealed that ITC-P-mP in suspension is capable of generating SO more efficiently than free ITC-P in solution.

show abstract

Advancements in Biomedical Micro/Nano Tools and Technology

Cited by 3 publications

References 20 publications

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

Micro/Nano Technology for Next‐Generation Diagnostics

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles

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