Advancements in Analyzing Tumor Metabolites through Chemical Derivatization-Based Chromatography

Lu, Yao; Zhang, Huamin; Zhou, B.; Tang, Weiyang; Zhou, Jian

doi:10.1016/j.chroma.2023.464236

Cited by 4 publications

(1 citation statement)

References 97 publications

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“…Derivatization is the key step to determine the sensitivity of the developed method, which is significantly affected by coexisting substances. , As shown in Figure a, derivatization efficiencies of four PASFs in (acetonitrile-based) soil extract were much lower than those in pure acetonitrile, while coexisting substances from soil extract significantly accelerated the derivatization efficiency of PASCl. For the derivatization of PASFs, redox is the reaction mechanism.…”

Section: Resultsmentioning

confidence: 99%

Nontarget Discovery of Per- and Polyfluoroalkyl Sulfonyl Halides in Soils by Integration of Derivatization and Specific Fragment-Based Liquid Chromatography-High Resolution Mass Spectrometry Screening

Wang,

Xiao,

Liu

et al. 2024

Environ. Sci. Technol.

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Though long recognized as synthetic precursors to other poly-and perfluoroalkyl substances (PFASs), most poly-and perfluoroalkyl sulfonyl halides (PASXs) cannot be directly measured and have generally received minimal attention. Inspired by the redox reaction between sulfonyl halide groups and ptoluenethiol in organic chemistry, we developed a novel nontarget analysis strategy for PASXs by intergrating derivatization and specific fragment-based liquid chromatography-high resolution mass spectrometry screening for m/z 82.961 [SO 2 F − ] and m/z 95.934 [S 2 O 2 − ]. By using this strategy, we discovered 11 PASXs, namely, perfluoroalkyl sulfonyl fluorides (5), polyfluoroalkyl sulfonyl fluorides (2), unsaturated perfluoroalkyl sulfonyl fluoride (1), and perfluoroalkyl sulfonyl chlorides (3) in soil samples collected from an abandoned fluorochemical manufacturing park. These average ∑PASXs concentrations were 1120 μg kg −1 (range: 9.7−9860 μg kg −1 ), which were very likely to be the key intermediates and undesired byproducts of electrochemical fluorination processes. Spatial variation in the mass ratio of ∑PASXs to ∑PFSAs (range: 0.7−795%) also indicates their different transportation pathways. More importantly, the decline of PASXs and increase of perfluoroalkyl sulfonates (when compared to a prior study at this site) suggest the continued hydrolysis of PASXs and the relatively fast environmental transformation rates in the abandoned fluorochemical park soils. Overall, these findings demonstrated the utility of a novel nontarget analysis strategy, which may change most PASXs from inferred precursors to measured intermediates and further could be adapted for structures, distribution, and transformation studies of PFASXs in other matrices.

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Section: Resultsmentioning

confidence: 99%