Advancements in accuracy of the alanine dosimetry system. Part 1. The effects of environmental humidity

Sleptchonok, O.; Nagy, Vitaly; Desrosiers, Marc F.

doi:10.1016/s0969-806x(99)00338-2

Cited by 67 publications

(42 citation statements)

References 20 publications

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“…It has been shown for relatively hygroscopic alanine samples that humidity changes from 20% to 80% decrease the cavity sensitivity by 7% (Sleptchonok et al, 2000). Since tooth enamel is less hygroscopic than alanine, the effect is expected to be smaller, although it has not been studied.…”

Section: Environmental Conditionsmentioning

confidence: 99%

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EPR dosimetry with tooth enamel: A review

Fattibene

Callens

2010

Applied Radiation and Isotopes

203

160

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When tooth enamel is exposed to ionizing radiation, radicals are formed that can be detected using Electron Paramagnetic Resonance (EPR) techniques. EPR dosimetry using tooth enamel is based on the (presumed) correlation between the intensity or amplitude of some of the radiation-induced signals with the dose absorbed in the enamel. In the present paper a critical review is given of this widely applied dosimetric method.The first part of the paper is quite fundamental and deals with the main properties of tooth enamel and several of its model systems (e.g., synthetic apatites). Considerable attention is also devoted to the numerous radiation-induced and native EPR signals, and the radicals responsible for them. The relevant EPR detection, identification and spectrum analysing methods are reviewed from a general point of view. Finally, the need for solid state modelling and the linearity of the dose response are investigated.The second part is devoted to the practical implementation of EPR dosimetry using enamel. It concerns the preparation of samples, specific irradiation problems, spectrum acquisition and it is described how the dosimetric signal intensity and dose can be retrieved from the EPR spectra. Special attention is paid to the energy dependence of the EPR response and to sources of uncertainties. Results of and problems encountered in international intercomparisons and epidemiological studies are also dealt with.In the final chapter the future of EPR dosimetry with tooth enamel is analysed.

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Section: Environmental Conditionsmentioning

confidence: 99%

“…Its broader, harder-to-saturate lines can be positioned virtually anywhere in the spectrum due to high spectrum anisotropy. It has been used in alanine dosimetry (Sleptchonok et al, 2000), but there have been no reports of its use in tooth dosimetry.…”

Section: Reference Samplesmentioning

confidence: 99%

EPR dosimetry with tooth enamel: A review

Fattibene

Callens

2010

Applied Radiation and Isotopes

203

160

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“…The alanine-polystyrene standard samples were left out overnight to allow for the known initial decrease in irradiated alanine signal. [15][16][17] Finally, the standard samples were placed in a mylar bag with desiccants, sealed under nitrogen, and placed in the freezer until testing. A polyacrylamide gel finger sized slab is formed from 35% acrylamide and the alanine-polystyrene standard samples were affixed creating the full-finger phantom, shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces

Sidabras

Varanasi

Mett

et al. 2014

Review of Scientific Instruments

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A microwave Surface Resonator Array (SRA) structure is described for use in Electron Paramagnetic Resonance (EPR) spectroscopy. The SRA has a series of anti-parallel transmission line modes that provides a region of sensitivity equal to the cross-sectional area times its depth sensitivity, which is approximately half the distance between the transmission line centers. It is shown that the quarter-wave twin-lead transmission line can be a useful element for design of microwave resonators at frequencies as high as 10 GHz. The SRA geometry is presented as a novel resonator for use in surface spectroscopy where the region of interest is either surrounded by lossy material, or the spectroscopist wishes to minimize signal from surrounding materials. One such application is in vivo spectroscopy of human finger-nails at X-band (9.5 GHz) to measure ionizing radiation dosages. In order to reduce losses associated with tissues beneath the nail that yield no EPR signal, the SRA structure is designed to limit depth sensitivity to the thickness of the fingernail. Another application, due to the resonator geometry and limited depth penetration, is surface spectroscopy in coating or material science. To test this application, a spectrum of 1.44 μM of Mg2+ doped polystyrene 1.1 mm thick on an aluminum surface is obtained. Modeling, design, and simulations were performed using Wolfram Mathematica (Champaign, IL; v. 9.0) and Ansys High Frequency Structure Simulator (HFSS; Canonsburg, PA; v. 15.0). A micro-strip coupling circuit is designed to suppress unwanted modes and provide a balanced impedance transformation to a 50 Ω coaxial input. Agreement between simulated and experimental results is shown.

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“…Alanine pellets were irradiated in tubes used for blood irradiation filled with water. For this reason, each pellet was wrapped and sealed in a thin plastic film to avoid humidification of the pellet, which causes an increase of the fading rate (Sleptchonok et al 2000).…”

Section: Epr Alanine Dosimetrymentioning

confidence: 99%

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation

Trompier

Baumann

Barrios

et al. 2016

International Journal of Radiation Biology

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Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation. ARTICLE HISTORY

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Advancements in accuracy of the alanine dosimetry system. Part 1. The effects of environmental humidity

Cited by 67 publications

References 20 publications

EPR dosimetry with tooth enamel: A review

EPR dosimetry with tooth enamel: A review

A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation

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