Advancements and future prospects of adeno-associated virus-mediated gene therapy for sensorineural hearing loss
Linke Li,
Tian Shen,
Shixi Liu
et al.
Abstract:Sensorineural hearing loss (SNHL), a highly prevalent sensory impairment, results from a multifaceted interaction of genetic and environmental factors. As we continually gain insights into the molecular basis of auditory development and the growing compendium of deafness genes identified, research on gene therapy for SNHL has significantly deepened. Adeno-associated virus (AAV), considered a relatively secure vector for gene therapy in clinical trials, can deliver various transgenes based on gene therapy strat… Show more
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