Advancement of Wnt signal pathway and the target of breast cancer

Qin, Liang; Li, Wei; Zhao, Zhanchao; Fu, Qiang

doi:10.1515/biol-2016-0013

Cited by 4 publications

(3 citation statements)

References 89 publications

(61 reference statements)

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“…Gene therapy is a remedial strategy that is considered to correct particular molecular deformities associated with the progression or development of breast cancer [ 242 ]. Mutated BRCA1 and p53 genes recognized as cancer susceptibility gene are involved in progression of cancer [ 243 ].…”

Section: Medicinal Plantsmentioning

confidence: 99%

Awareness and current knowledge of breast cancer

Akram¹,

et al. 2017

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Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the leading cause of mortality among women population. For the previous two decades, studies related to the breast cancer has guided to astonishing advancement in our understanding of the breast cancer, resulting in further proficient treatments. Amongst all the malignant diseases, breast cancer is considered as one of the leading cause of death in post menopausal women accounting for 23% of all cancer deaths. It is a global issue now, but still it is diagnosed in their advanced stages due to the negligence of women regarding the self inspection and clinical examination of the breast. This review addresses anatomy of the breast, risk factors, epidemiology of breast cancer, pathogenesis of breast cancer, stages of breast cancer, diagnostic investigations and treatment including chemotherapy, surgery, targeted therapies, hormone replacement therapy, radiation therapy, complementary therapies, gene therapy and stem-cell therapy etc for breast cancer.

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Section: Medicinal Plantsmentioning

confidence: 99%

Awareness and current knowledge of breast cancer

Akram¹,

et al. 2017

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“…Gene therapy utilizes virus to deliver and replicate new genes into patients' cells to replace damaged genes. This approach is a very selective targeted approach for precise molecular abnormalities associated with development of breast cancer, like mutated BRCA1 and p53 genes [49,50].…”

Section: Targeted Breast Cancer Therapymentioning

confidence: 99%

Targeted Breast Cancer Treatment Using New Photochemotherapeutic Compounds

Tynga¹,

Abrahamse²

2020

Breast Cancer Biology

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The deregulation of cell growth in milk-producing glands, milk-carrying tubes, or connective tissues is known as breast cancer. It originates from genetic mutations and has the ability to metastasize. Primary tumor cells repetitively divide and lead to inappropriate mechanisms, tumorigenesis, and carcinogenesis, characterized by improper cell type, function, lifetime, and self-destruction. The tumor-specific activation is considered to be an effective strategy for selective cancer destruction, which remains an issue with conventional therapeutic approaches. The tumor microenvironment can be regulated and adapted through an interaction between pH, proteins, and other factors. Principally, human breast cancer genes, BRCA1 and BRCA2, produce tumor suppressors that prevent changes in genetic materials, as well as ensure their stability. Photodynamic therapy is a targeted cancer modality that depends on the photochemotherapeutic agent and light characteristics used to activate the compound. The possibility of eradicating breast cancer depends on continuous development of therapeutic approaches using third-generation photochemotherapeutic compounds to improve targeting this cancer and its stem cells.

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“…EMT is a dynamic process that appears to facilitate tumour metastasis by switching the cell phenotype from epithelial to mesenchymal (122,123). Furthermore, nestin silencing significantly upregulated the expression of proteins involved in the inhibition of the Wnt/β-catenin pathway, which is crucial for the regulation of the proliferation and tumorigenicity of stem cells (124)(125)(126)(127). In addition, the inhibition of the Wnt/β-catenin pathway in nestin high CSCs significantly limited their tumorigenicity.…”

Section: Nestin As a Marker Of Bc Stem Cellsmentioning

confidence: 99%

Implications of nestin in breast cancer pathogenesis (Review)

Nowak

Dzięgiel

2018

Int J Oncol

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The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC and other cancer types. In normal breast tissue, nestin is expressed in the basal/myoepithelial cells of the mammary gland. In BC, nestin identifies basal-like tumours and predicts aggressive behaviour and poor prognosis. Nestin expression has also been detected in BC stem cells and newly-formed tumour vessels, being a factor in promoting invasion and metastasis. The present review provides an up-to-date overview of the involvement of nestin in processes facilitating BC pathogenesis and progression.

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Advancement of Wnt signal pathway and the target of breast cancer

Cited by 4 publications

References 89 publications

Awareness and current knowledge of breast cancer

Awareness and current knowledge of breast cancer

Targeted Breast Cancer Treatment Using New Photochemotherapeutic Compounds

Implications of nestin in breast cancer pathogenesis (Review)

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