Advancement in the synthesis of metal complexes with special emphasis on Schiff base ligands and their important biological aspects

Singh, Preeti; Yadav, Preeti; Kaur Sodhi, Kushneet; Tomer, Anurag; Bali Mehta, Shilpika

doi:10.1016/j.rechem.2023.101222

Cited by 9 publications

(6 citation statements)

References 135 publications

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“…We note that the synthesis of new SBs ligands is still attractive because it exhibits comprehensive analytical, biological, physico-chemical, catalytical, and structural properties [32][33][34]. For example, easily accessible polydentate SBs and their metal complexes are essential in pharmacy and medicine [35]. Developing novel SBs as ligands can effectively fight against the current antimicrobial, anticancer, and antioxidant resistance threat.…”

Section: Future Prospects and Conclusionmentioning

confidence: 99%

“…Due to their physicochemical properties (solubility and stability in water, change in polarity, structural properties), the obtained compounds can be used for chromatographic analysis of biogenic amines in complex matrices, such as food samples. Moreover, based on their antimicrobial and antioxidative activity and ability to form complexes with various metal ions, they can be considered promising for future applications in biology, catalysis, or designing newer therapeutic agents [35,36].…”

Section: Future Prospects and Conclusionmentioning

confidence: 99%

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New Water-Soluble (Iminomethyl)benzenesulfonates Derived from Biogenic Amines for Potential Biological Applications

Kmieciak,

Krzemiński,

Hodii

et al. 2024

Materials

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In this paper, a highly efficient and straightforward method for synthesizing novel Schiff bases was developed by reacting selected biogenic amines with sodium 2-formylbenzene sulfonate and sodium 3-formylbenzene sulfonate. 1H and 13C NMR, IR spectroscopy, and high-resolution mass spectrometry were used to characterize the new compounds. The main advantages of the proposed procedure include simple reagents and reactions carried out in water or methanol and at room temperature, which reduces time and energy. Moreover, it was shown that the obtained water-soluble Schiff bases are stable in aqueous solution for at least seven days. Additionally, the antioxidant and antimicrobial activity of synthesized Schiff bases were tested.

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Section: Future Prospects and Conclusionmentioning

confidence: 99%

Section: Future Prospects and Conclusionmentioning

confidence: 99%

New Water-Soluble (Iminomethyl)benzenesulfonates Derived from Biogenic Amines for Potential Biological Applications

Kmieciak,

Krzemiński,

Hodii

et al. 2024

Materials

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show abstract

“…Schiff bases have a wide range of applications in various fields, including medicine, pharmacology, and materials science, due to their diverse chemical properties and biological activities. The pharmacological properties of Schiff bases are attributed to the presence of aromatic rings with oxygen, sulfur, and nitrogen donor atoms, which contribute to their wide range of activities such as anti-inflammatory, antimalarial, antibacterial, antipyretic actions, and antifungal [3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Molecular docking studies, structural analysis, biological studies, and synthesis of certain novel Schiff base from benzohydrazide derivate

Gosu,

et al. 2024

Phys. Scr.

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The research described involves the synthesis and characterization of a new benzohydrazide based Schiff base compound namely 4-methyl-N'-(2,4,5-trimethoxybenzylidene) benzohydrazide (HL). The compound was synthesized by condensing a primary amine and an aldehyde functional group. The characterization of the compound was carried out using various spectroscopic techniques, including elemental analysis, Ultraviolet spectroscopy, nuclear magnetic resonance spectroscopy, and infrared spectroscopy. These techniques helped confirm the excellent quality of the synthesized molecules. In addition to the characterization, the Schiff base compound was subjected to docking studies and biological studies. The antibacterial activity of the compound was tested against three strains of bacteria, namely E. faecalis, B. subtills, and E.coli. The results of these tests provided information on the compound effectiveness against these bacterial strains. Furthermore, docking studies was performed to assess the interaction between the synthesized compound and three target enzymes like GlcN-6-p synthase, DNA polymerase, and EGFR tyrosine kinase. Docking studies are computational simulations that provide insights into the binding interactions between Schiff base ligand and target proteins. In this case, the docking studies helped understand the potential mechanisms of action of the synthesized compound by calculating binding constants and the number of binding modes. The biological activity studies revealed interesting fragmentation patterns, which could be further investigated to understand the compound modes of action. Moreover, the docking studies evaluated the compound's potential as a drug candidate by assessing its binding interactions with the target enzymes. The present study suggests that the synthesized benzohydrazide based Schiff base compound exhibits potential antibacterial activity and shows promising binding interactions with the target protein/enzymes. This information is valuable for designing and developing more potent compounds in the future.

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“…[5][6][7][8] The unique structural characteristics and chemical properties exhibited by metal complexes derived from Mn(II), Cu(II), and Ni(II) render them highly promising for a range of applications, including the fields of biology and medicine. [9,10] In recent years, significant research efforts have been devoted to assessing the antioxidant capabilities of these metal complexes. This focus stems from the recognition that oxidative stress and the detrimental effects caused by free radicals play a role in various pathological conditions such as cancer, cardiovascular diseases, neurodegenerative disorders, and the aging process.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Lawan,

Mshelia,

Mala

et al. 2024

ChemistrySelect

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Metal complexes derived from Schiff bases are known to have a wide range of applications, spanning the areas of material and medicinal sciences. Herein, a Schiff base ligand, (Z)‐2‐(((4‐chlorophenyl)imino)methyl)naphthalen‐1‐ol HL, was synthesized via a condensation reaction between 2‐hydroxy‐1‐naphthaldehyde and 4‐chloroaniline using methanol as a solvent in the presence of a catalytic amount of formic acid. The obtained ligand was further reacted with Mn(II), Ni(II), and Cu(II) using their acetate salts in a 1 : 2 stoichiometric ratio of metal to ligand to afford complexes C1–C3, respectively. Physicochemical and analytical techniques consisting of FTIR, UV‐Vis, elemental (CHN and metal content), TGA, HRMS, 1H, and 13 C NMR spectroscopy were deployed to establish the formation of the compounds. Results show that the ligand coordinated with the metal ions through the oxygen and nitrogen atoms of the phenolate and azomethine moieties, respectively, forming ON‐type complexes. Furthermore, the free ligand and its complexes were evaluated for their antioxidant activity compared to the standard (ascorbic acid) using an in vitro DPPH radical scavenging assay. From this investigation, C1 demonstrated higher radical scavenging activity than the free ligand, the complexes, and the standard (ascorbic acid). But the ligand has better scavenging activity than C2 and C3 at higher concentrations. DFT was also used to examine the electronic properties of the compounds, and the data obtained corroborated well with the experimental study.

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Advancement in the synthesis of metal complexes with special emphasis on Schiff base ligands and their important biological aspects

Cited by 9 publications

References 135 publications

New Water-Soluble (Iminomethyl)benzenesulfonates Derived from Biogenic Amines for Potential Biological Applications

New Water-Soluble (Iminomethyl)benzenesulfonates Derived from Biogenic Amines for Potential Biological Applications

Molecular docking studies, structural analysis, biological studies, and synthesis of certain novel Schiff base from benzohydrazide derivate

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

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