Advancement in Photothermal Effect of Carbon Nanotubes by Grafting of Poly(amidoamine) and Deposition of CdS Nanocrystallites

Neelgund, Gururaj M.; Oki, Aderemi

doi:10.1021/acs.iecr.7b04732

Cited by 21 publications

(12 citation statements)

References 49 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overall, a systematical improvement in the PTE of the GR nanosheets and ZnO particles is achieved by their perfect combination and subsequent sensitization with CoPc. The advancement in the PTE of GR–ZnO and GR–ZnO–CoPc was precisely estimated through estimation of their photothermal conversion efficiency (η) by means of Roper’s method using eq − where η is the photothermal efficiency, h is heat-transfer coefficient, and S is the surface area of the sample container. T max is the maximum temperature attained by the sample, and T surr is the surrounding temperature.…”

Section: Resultsmentioning

confidence: 99%

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Neelgund

Oki

2019

ACS Omega

Self Cite

View full text Add to dashboard Cite

Herein, a promising near-infrared-responsive photothermal agent was designed by anchoring of rice grain-shaped ZnO particles over graphene (GR) nanosheets and subsequent sensitization with cobalt phthalocyanine (CoPc). Thus, produced GR–ZnO–CoPc was able to attain the temperature of 68 °C by irradiating to 980 nm laser for 7 min, which is extremely higher than the endurance temperature of cancer cells. The linear fashioned progression in the photothermal effect of GR nanosheets was conquered by immobilization of ZnO particles and successive sensitization with CoPc. The excellence found in the photothermal effect of GR–ZnO–CoPc was verified by estimation of its photothermal conversion efficiency. The photothermal conversion efficiency assessed for GR–ZnO–CoPc was higher than those for the popular gold- and CuS-based photothermal agents. In addition, it possessed significant stability against photobleaching and structural rupture. It was found that the photothermal effect of GR–ZnO–CoPc is proportional to its concentration. However, by replacement of a 980 nm laser system with 808 nm, the photothermal effect of GR–ZnO–CoPc was reduced, which could be due to lower absorption of GR–ZnO–CoPc at 808 nm compared to 980 nm. On account of its significance and important properties, GR–ZnO–CoPc could be an interesting photothermal agent to employ in future photothermal therapy for cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Neelgund

Oki

2019

ACS Omega

Self Cite

View full text Add to dashboard Cite

show abstract

“…The most commonly used photothermal agents include gold, carbon, and magnetic nanoparticles, graphene, NIR dyes, or some polymer nanoparticles (i.e., polyaniline, polypyrrole). , Despite the extraordinary photothermal effects, the long-term safety issue of these synthetic materials remains as a major concern. For instance, metallic nanoparticles might cause metal-related cytotoxicity in biological systems, and carbon-based nanomaterials can induce oxidative stress and lung inflammation after administration. , Furthermore, preparations of these materials require tedious synthetic processes, which are time- and energy-consuming. ,− Therefore, it is required to find an alternative material with efficient photothermal conversion efficiency, good price, and easy availability, as well as human-benign nature.…”

Section: Introductionmentioning

confidence: 99%

Natural Melanin/Polyurethane Composites as Highly Efficient Near-Infrared-Photoresponsive Shape Memory Implants

Xie

Yan

Pakdel

et al. 2020

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Natural melanin is recognized as a biocompatible photothermal agent because of its biologically derived nature and efficient photothermal conversion ability. Here, yak hair melanin (YM) is added to polyurethane (PU) for the fabrication of NIR-photoresponsive shape memory implants. The in vitro toxicity of the YM/PU composites is carried out by exposing them to human mesenchymal stem cells (hMSCs) and mouse fibroblast (L929) cells lines for 24 h, while the in vivo toxicity is investigated by implanting the YM/PU composites in the mouse for two months. No significant differences on cell viability, blood chemistry, hematology, and histological results are observed between YM/PU composites and control groups, suggesting their excellent biocompatibility. The biostability of the YM/PU composites is confirmed by monitoring their in vitro degradation for 12 weeks. The YM/PU column implanted in the back subcutis or vagina of the mouse rapidly recovered to its original state within 60 s under a very low NIR laser (808 nm, 0.5 W/cm2) intensity, which is much lower than the general laser intensity for photothermal cancer therapy (1–2 W/cm2). This work confirms the applicability of the YM/PU composites as long-term implant materials and expedites the use of YM/PU composites as cost-effective candidates for biomedical applications.

show abstract

“…Due to several unique and desirable properties, such as high tensile strength and electrical conductivity, carbon nanotubes (CNTs), a group of engineered carbonaceous nanomaterials, are used in various commercial and industrial applications. − In addition, their near-infrared absorption and photoemission characteristics are being explored for various biomedical applications such as photothermal therapy and bioimaging. − The increased use of CNTs implicates a heightened risk of human exposure and adverse health consequences, partly due to their biological activities and persistence, − which have increasingly been reported. Inhaled CNTs can reach the interstitial alveolar region and remain trapped for an extended period of time due to impaired phagocytic clearance by macrophages, − leading to chronic diseases such as pulmonary fibrosis. , …”

Section: Introductionmentioning

confidence: 99%

SOX2Mediates Carbon Nanotube-Induced Fibrogenesis and Fibroblast Stem Cell Acquisition

Kiratipaiboon

Voronkova

Ghosh

et al. 2020

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Certain nanosized particles like carbon nanotubes (CNTs) are known to induce pulmonary fibrosis, but the underlying mechanisms are unclear, and efforts to prevent this disease are lacking. Fibroblast-associated stem cells (FSCs) have been suggested as a critical driver of fibrosis induced by CNTs by serving as a renewable source of extracellular matrix-producing cells; however, a detailed understanding of this process remains obscure. Here, we demonstrated that single-walled CNTs induced FSC acquisition and fibrogenic responses in primary human lung fibroblasts. This was indicated by increased expression of stem cell markers (e.g., CD44 and ABCG2) and fibrogenic markers (e.g., collagen and α-SMA) in CNT-exposed cells. These cells also showed increased sphere formation, anoikis resistance, and aldehyde dehydrogenase (ALDH) activities, which are characteristics of stem cells. Mechanistic studies revealed sex-determining region Y-box 2 (SOX2), a self-renewal associated transcription factor, as a key driver of FSC acquisition and fibrogenesis. Upregulation and colocalization of SOX2 and COL1 were found in the fibrotic lung tissues of CNT-exposed mice via oropharyngeal aspiration after 56 days. The knockdown of SOX2 by gene silencing abrogated the fibrogenic and FSC-inducing effects of CNTs. Chromatin immunoprecipitation assays identified SOX2-binding sites on COL1A1 and COL1A2, indicating SOX2 as a transcription factor in collagen synthesis. SOX2 was also found to play a critical role in TGF-β-induced fibrogenesis through its collagen- and FSC-inducing effects. Since many nanomaterials are known to induce TGF-β, our findings that SOX2 regulate FSCs and fibrogenesis may have broad implications on the fibrogenic mechanisms and treatment strategies of various nanomaterial-induced fibrotic disorders.

show abstract

Advancement in Photothermal Effect of Carbon Nanotubes by Grafting of Poly(amidoamine) and Deposition of CdS Nanocrystallites

Cited by 21 publications

References 49 publications

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Natural Melanin/Polyurethane Composites as Highly Efficient Near-Infrared-Photoresponsive Shape Memory Implants

SOX2Mediates Carbon Nanotube-Induced Fibrogenesis and Fibroblast Stem Cell Acquisition

Contact Info

Product

Resources

About