Advancement in nanogel formulations provides controlled drug release

Ahmed, Shayan; Alhareth, Khair; Mignet, Nathalie

doi:10.1016/j.ijpharm.2020.119435

Cited by 79 publications

(63 citation statements)

References 111 publications

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“…In general, nanogels such as the thiol-conjugated hyaluronic acid and disulfide cross-linked dextrin or chitosan particles have been used to encapsulate siRNA or DNA in nanogels. These nanogels obtained by ionic gelation allow an efficient encapsulation of nucleic acids [10,29].…”

Section: Size and Charge Characterization Of Neutral Formulations And Their Sirna Encapsulation Efficiency And Loading Contentmentioning

confidence: 99%

“…The majority of non-viral vectors which are already described in the literature are positively charged for gene delivery including, liposomes, polymers, nanocrystals, inorganic materials, micelles, and proteins in order to facilitate their interaction with anionic nucleic acids and to provide cell interaction and internalization, which will lead to better transfection efficiency [7][8][9]. However, this cationic charge can impair their circulation time, intracellular release efficiency, and cause toxicity [10][11][12]. The titratable lipids developed more recently were shown to produce significantly long-circulating lipoplexes with reduced toxicity and nucleic acid delivery at a lower pH [13].…”

Section: Introductionmentioning

confidence: 99%

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Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged

et al. 2021

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Since its discovery, evidence that siRNA was able to act as an RNA interference effector, led to its acceptation as a novel medicine. The siRNA approach is very effective, due to its catalytic mechanism, but still the limitations of its cellular delivery should be addressed. One promising form of non-viral gene delivery system is liposomes. The variable and versatile nature of the lipids keeps the possibility to upgrade the liposomal structure, which makes them suitable for encapsulation and delivery of drugs. However, to avoid the limitation of fast release for the hydrophilic drug, we previously designed viscous core liposomes. We aimed in this work to evaluate if these viscous core liposomes (NvcLs) could be of interest for siRNA encapsulation. Then, we sought to add a limited amount of positive charges to provide cell interaction and transfection. Cationic lipid dimyristoylaminopropylaminopropyl or the polymer poly(ethylenimine) were incorporated in NvcL to produce positively charged viscous core liposomes (PvcL) by a customized microfluidic device. We found that NvcLs increased the encapsulation efficiency and loading content with regards to the neutral liposome. Both PvcLPEI and PvcLDMAPAP exhibited transfection and GFP knock-down (≈40%) in both 2D and 3D cell cultures. Finally, the addition of slight positive charges did not induce cell toxicity.

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Section: Size and Charge Characterization Of Neutral Formulations And Their Sirna Encapsulation Efficiency And Loading Contentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged

et al. 2021

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“…This unique property enables hydrogels to be used in tissue engineering and drug delivery (Peppas et al, 2006;Brandl et al, 2007;Bawa et al, 2009;;Das et al, 2021;Nai et al, 2021). Nanogels are hydrogels with the size being around 1-1000 nm (Ahmed et al, 2020). They can carry and protect the active ingredients loaded inside, and can sense and respond to external stimuli by exhibiting changes in the gel volume, water content, colloidal stability, mechanical strength, and other physical/ chemical properties (Wu & Tian, 2008;He et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Preparation and use of nanogels as carriers of drugs

Obireddy

Lai

2021

Drug Delivery

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Nanogels have high tunability and stability while being able to sense and respond to external stimuli by showing changes in the gel volume, water content, colloidal stability, mechanical strength, and other physical/chemical properties. In this article, advances in the preparation of nanogels will be reviewed. The application potential of nanogels in drug delivery will also be highlighted. It is the objective of this article to present a snapshot of the recent knowledge of nanogel preparation and application for future research in drug delivery.

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“…[3][4][5] Specifically, smart nanogels are able to respond to an external stimuli such as pH and temperature. [6][7][8][9] Nanogels are one of the most attractive soft materials which are of considerable interest in areas such as drug delivery, [10][11][12][13] tissue engineering, [14][15][16] water treatment, [17][18][19][20] food packaging, [21][22][23] diagnostics, [24,25] imaging [26][27][28] and emulsion stabilizing. [29][30][31] are formed between one polymer chain and another via crosslinkers that can form ester or ether bonds.…”

Section: Introductionmentioning

confidence: 99%

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

Saracoglu

Ozmen

2021

Starch Stärke

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Nanogels are nanosized three-dimensional polymeric networks that are able to swell in a solvent. They are of great interest due to their high surface area, response to environmental stimuli, and high loading efficiency. In recent years, nanogels prepared from polysaccharides have captured broad attention because of their superior biocompatibility, easy gelation, and functionalization. In particular, starch based nanogels (SBNs) are promising nanomaterials for versatile applications including biomedical, food and pharmaceutical industries. Despite a high number of publications for other polysaccharide nanogels, a limited number of SBNs research articles are available in the literature. This review provides a brief summary of previous studies on the synthesis and applications of SBNs. Their current status is specified briefly covering the last decade. Some studies reveal that starch type, gelation time, and amylose/amylopectin ratio are critical parameters during SBNs synthesis. Numerous starch derivatives and combinations of starch with various polymers can facilitate their synthesis with desired features. Importantly, in vivo biodegradability and biocompatibility investigations are required to extend SBNs usage in the biomedical field including drug and peptide delivery. The overview provided by this review will offer a valuable understanding and insight to help direct the design and uses of SBNs.

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Advancement in nanogel formulations provides controlled drug release

Cited by 79 publications

References 111 publications

Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged

Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged

Preparation and use of nanogels as carriers of drugs

Starch Based Nanogels: From Synthesis to Miscellaneous Applications

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