2021
DOI: 10.1016/j.sna.2021.112792
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Advanced vapour sensing materials: Existing and latent to acoustic wave sensors for VOCs detection as the potential exhaled breath biomarkers for lung cancer

Abstract: Lung cancer is the leading cause of death worldwide and has a significant impact on public health across society. Among all types of cancer, lung cancer is typically silent and it is commonly diagnosed at a later stage where treatment is rarely achievable. There is an urgent need for the development of the early diagnosis of lung cancer for an improved survival rate. Preliminary research shows that lung cancer is accompanied by increased oxidative stress which generates volatile organic compounds (VOCs). Hence… Show more

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Cited by 29 publications
(12 citation statements)
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“…Similar to QCM sensors, MOS including ZnO, SiO 2 , TiO 2 , Co 3 O 4 , WO 3 , and other combinations [ 7 , 172 ], have been used extensively for SAW devices and most commonly for selective VOCs detection. For example, ethanol detection has been achieved at 300 °C using a YX LiTaO 3 -based SAW sensor modified with a ZnO intermediate layer of 1.2 μm and a WO 3 sensing layer of 150 nm [ 177 ]; porous ZnO-SiO 2 bilayer nano-films have been used for NH 3 detection, with SAW sensor sensitivity being better than the one for single layers and was found to be dependent on bi-film conductivity [ 178 ].…”
Section: Types Of Nanomaterial-based Sensors In Breath Analysismentioning
confidence: 99%
See 1 more Smart Citation
“…Similar to QCM sensors, MOS including ZnO, SiO 2 , TiO 2 , Co 3 O 4 , WO 3 , and other combinations [ 7 , 172 ], have been used extensively for SAW devices and most commonly for selective VOCs detection. For example, ethanol detection has been achieved at 300 °C using a YX LiTaO 3 -based SAW sensor modified with a ZnO intermediate layer of 1.2 μm and a WO 3 sensing layer of 150 nm [ 177 ]; porous ZnO-SiO 2 bilayer nano-films have been used for NH 3 detection, with SAW sensor sensitivity being better than the one for single layers and was found to be dependent on bi-film conductivity [ 178 ].…”
Section: Types Of Nanomaterial-based Sensors In Breath Analysismentioning
confidence: 99%
“…CNTs, SWCNTs, and MWCNTs dispersed in ethanol or toluene for example, have been separately tested for ethanol, toluene, and ethyl acetate sensing at RT with a LOD of 1 ppm [ 184 ]. The main advantage of CNTs-modified sensors is the enhanced SAW sensor-sensitivity, due to the ability to sense variations not only in mass but also in conductivity [ 172 ].…”
Section: Types Of Nanomaterial-based Sensors In Breath Analysismentioning
confidence: 99%
“… 8 For instance, the breath of patients infected with tuberculosis (TB) shows increased levels of several benzene and aldehyde derivatives, 10 and acetone is highly related to diabetes detection. 11 Using VOCs to detect various diseases and metabolic disorders such as cancers, kidney failure, liver disease, and Alzheimer’s disease has been studied in the past, 9 , 12 14 and a similar approach has been recently expanded to include COVID-19 diagnosis. 5 , 15 , 16 From studies conducted by Berna et al 5 and Miller et al., 16 heptanal has been identified as one of the key biomarkers which was significantly elevated in the breath of SARS-CoV-2 patients.…”
Section: Introductionmentioning
confidence: 99%
“…There are several major technologies in VOC detection, including gas chromatography–mass spectrometry (GCMS) and chemo-resistive devices, as well as sensor-based diagnosis. 11 Recognized as the gold standard, GC-MS has been widely used in clinical trials in breath VOC detection. 17 , 18 However, it is time-consuming and requires bulky, expensive equipment and highly trained professionals.…”
Section: Introductionmentioning
confidence: 99%
“…Here, we provide a comprehensive review of the rapidly growing scientific literature on the development of IL-coated QCM sensors/sensor arrays and their applications for the analysis of complex mixtures of VOCs. Interested readers are referred to recently published reviews that cover other QCM sensing materials [39][40][41][42][43]. This manuscript summarizes: (i) The working principle of QCM and QCM-D (quartz crystal microbalance with dissipation monitoring); (ii) ILs and their characteristic properties that make them suitable sensing materials for QCM; (iii) recent advances in IL-coated QCM sensors and multi-sensor arrays; and (iv) recent advances in IL-coated virtual sensor arrays and their applications.…”
Section: Introductionmentioning
confidence: 99%