Advanced ultrasound in the diagnosis of prostate cancer

Corréas, Jean-Michel; Halpern, Ethan J.; Barr, Richard G.; Ghai, Sangeet; Walz, Jochen; Bodard, Sylvain; Dariane, C.; Rosette, Jean de la

doi:10.1007/s00345-020-03193-0

Cited by 44 publications

(35 citation statements)

References 87 publications

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“…Micro-ultrasonography (MicroUS) is referred to as frequencies of 14–29 MHz, which can offer a spatial resolution of 50–70 μm, with an up to 94% increase in PCa detection rate and AUC of 0.60–0.80. In this context, multicenter trials are necessary to confirm this new imaging device [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

“…It provides a color-coded image, with the less elastic zones colored in blue. It is not PCa specific, and the results for the moment are confounding [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

“…It can distinguish peripheral nodules from BPH or macro-calcifications, and it can estimate Gleason score from stiffness. SWE is not powerful enough to exclude PCa without a prostate biopsy [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

“…Both SE and SWE present limitations when facing large prostate glands; not all stiff lesions are cancers and not all cancers present stiffness [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

“…It can identify vascular and microvascular architecture or irregularities around PCa. CEUS can enhance Doppler sensitivity from 54% to 93% and specificity from 79% to 87% in diagnosing hypervascular PCa nodules [ 64 ]. In a large prospective study, with 1024 patients, CEUS helped identify 20.5% more csPCa at biopsy, including 15.6% PCa missed by standard biopsy [ 65 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

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PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer

Munteanu

Gulei

et al. 2020

Diagnostics

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Prostate cancer represents the most encountered urinary malignancy in males over 50 years old, and the second most diagnosed after lung cancer globally. Digital rectal examination and prostatic specific antigen were the long-time standard tools for diagnosis but with a significant risk of overdiagnosis and overtreatment. Magnetic resonance imaging recently entered the diagnosis process, but to this date, there is no specific biomarker that accurately indicates whether to proceed with the prostate biopsy. Research in this area has gone towards this direction, and recently, serum, urine, imagistic, tissue biomarkers, and Risk Calculators promise to help better diagnose and stratify prostate cancer. In order to eliminate the comorbidities that appear along with the diagnosis and treatment of this disease, there is a constant need to implement new diagnostic strategies. Important uro-oncology associations recommend the use of novel biomarkers in the grey area of prostate cancer, to better distinguish the next step in the diagnostic process. Although it is not that simple, they should be integrated according to the clinical policies, and it should be considered that statistical significance does not always equal clinical significance. In this review, we analyzed the contribution of prostate-specific antigen (PSA)-based biomarkers (PHI, PHID, 4Kscore, STHLM3), imagistic techniques (mp-MRI and mp-US), and combined tests in the early diagnosis process of localized prostate cancer.

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Section: Imagistic Techniquesmentioning

confidence: 99%

“…It provides a color-coded image, with the less elastic zones colored in blue. It is not PCa specific, and the results for the moment are confounding [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

Section: Imagistic Techniquesmentioning

confidence: 99%

“…Both SE and SWE present limitations when facing large prostate glands; not all stiff lesions are cancers and not all cancers present stiffness [ 64 ].…”

Section: Imagistic Techniquesmentioning

confidence: 99%

Section: Imagistic Techniquesmentioning

confidence: 99%

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