Advanced trends in controlling Helicobacter pylori infections using functional and therapeutically supplements in baby milk

Abstract

Helicobacter pylori is a common human pathogen infecting about 30 % of children and 60 % of adults worldwide. It is responsible for diseases such as gastritis, peptic ulcer and gastric cancer. H. pylori treatment based on antibiotics with proton pump inhibitor, but therapy failure is shown to be higher than 20 % and is essentially due to an increasing in prevalence of antibiotic-resistant bacteria, which has led to the search for alternative therapies. In this study, we discuss the usage of natural extracts mixture as alternative or complementary agents in controlling H. pylori infection so here, we focused on the plant extracts of (Cloves, Pepper, Cumin, Sage, Pomegranate peel, Ginger, Myrrh and Licorice). To that end, Phytochemical constituents detection like Tannins, Glycosides, Alkaloids, Flavonoids, Terpenoids, Saponins, Phenolic compounds, Reducing sugars, Volatile oils, Amino acids and Proteins was demonstrated. Each plant extract was examined individually or in combination for its antimicrobial activity against H. pylori. Out of the used extracts, four mixes were prepared and tested against H. pylori. The antibacterial activities of the four mixes, represented by the diameter of inhibition clear zone, recorded 21, 39, 23 and 28 mm. The most potent mix (mix2) was chosen and mixed with baby milk as a new combination for H. pylori infections treatment in babies.

Syzygium aromaticum L.: Traditional herbal medicine against cagA and vacA toxin genes-producing drug resistant Helicobacter pylori

“…Our results are in agreement with Hamada et al. 50 who found that 85.7% of H. pylori isolates were resistant to AX, 71.4% of the isolates were resistant to AM, while 57.1% were resistant to ERY. Rasheed et al.…”

“…These results are in agreement with Hamad et al. 50 who studied the cytotoxicity of different herbal extracts and reported that even up to the maximum concentration (20 mg/ml), the extracts did not reach IC 50 and showed an inhibition rate of 22.51%.…”

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control &amp; Prevent Food Contamination

“…A set of 6 concentration of reconstituted plant water extracts (75, 50, 25, 12.5, 6.25 and 3.1 mg/ mL), were examined to determine the minimum inhibitory concentration (MIC) of each against a specific pathogenic strain. [19,20] The zone of inhibition was calculated by measuring the diameter of the inhibition zone around the well (mm), including the well diameter. The readings were taken in three different fixed directions in all triplicates and the average values were tabulated.…”

“…The ability of the plant extracts to scavenge DPPH free radicals was assessed by the standard method of [20,24]. Adopted with suitable modifications [22].…”

Feeding preference of Altica deserticola for leaves of Glycyrrhiza glabra and G. uralensis and its mechanism

“…They are natural polyphenolic compounds and widely exist in leguminous plants. Previous studies reported that leaves of liquorice plants contained tannins, and tannic acid, catechin, ellagic acid, and gallic acid were four major components [31][32][33][34] . We determined the content of total tannins and their four components in the leaves of the two liquorices.…”