Advanced Transport Phenomena

Leal, L. Gary

doi:10.1017/cbo9780511800245

Cited by 932 publications

(482 citation statements)

References 0 publications

Supporting

Mentioning

441

Contrasting

Order By: Relevance

“…The relative importance of inertia can be quantified by Reynolds number (Re ¼ qUD h =l) which describes the ratio of inertial to viscous forces, with q; l, and U being 1=2 /viscous force the density, viscosity, and mean velocity of the fluid, respectively, while D h is the hydraulic diameter of the channel implying the actual diameter in case of a circular tube and equal to 2WH=ðW þ HÞ for a rectangular channel with width W and height H. It can be shown 41 that in the limit of zero Reynolds number, i.e., Stokes flow, lateral migration of a neutrally buoyant particle suspended in a confined flow of a Newtonian fluid is nonexistent due to linearity and thus reciprocality of the system. But in the flow regime where Re տ Oð1Þ, in addition to the drag force in the axial direction, transverse forces are exerted on the suspended particles compelling them to migrate laterally towards final stable locations, also known as equilibrium positions.…”

Section: A Inertial Effectsmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

View full text Add to dashboard Cite

Focusing and sorting cells and particles utilizing microfluidic phenomena have been flourishing areas of development in recent years. These processes are largely beneficial in biomedical applications and fundamental studies of cell biology as they provide cost-effective and point-of-care miniaturized diagnostic devices and rare cell enrichment techniques. Due to inherent problems of isolation methods based on the biomarkers and antigens, separation approaches exploiting physical characteristics of cells of interest, such as size, deformability, and electric and magnetic properties, have gained currency in many medical assays. Here, we present an overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels. Our emphasis is on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows. We also highlight the advantages and drawbacks of each method in terms of throughput, separation efficiency, and cell viability. Finally, we discuss the future research areas for extending the scope of hydrodynamic mechanisms and exploring new physical directions for microfluidic applications.

show abstract

Section: A Inertial Effectsmentioning

confidence: 99%

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

2013

View full text Add to dashboard Cite

show abstract

“…at the creeping-flow limit, which is known as Stoke's law [41], where a is the particle radius,ũ is the fluid velocity,ũ p is the particle velocity andm is the viscosity of the liquid. The DEP force for a spherical particle is given in Eq.…”

Section: Optimization Of the Separation Channelmentioning

confidence: 99%

“…When the particle moves close to the channel wall, there exists a strong dielectric [42] and hydrodyanmic [41] interaction between the particle and the channel wall, resulting in a repulsive force. Therefore, at some critical spacing between particle and the channel wall, repulsion force on the particle balances the DEP force, which would prevent the sticking of the particle on the channel wall.…”

Section: Simulation Of the Particle Trajectorymentioning

confidence: 99%

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Çetin

2009

Electrophoresis

View full text Add to dashboard Cite

A design of a microchannel for continuous separation of particles based on alternating current dielectrophoretic is studied. The geometric design parameters are determined by analyzing the dielectrophoresis force field inside the microchannel corresponding to the most efficient separation. The trajectories of 5 and 10 mm spherical particles are derived analytically using Lagrangian tracking method to examine the feasibility and the effectiveness of the design. The effects of the mean flow velocity inside the channel and the applied voltage across the channel on the performance of the separation are also discussed.

show abstract

“…w(0) = w (0) = w(L) = w (L) = 0 (with primes denoting differentiation with respect to x). To determine the pressure within the liquid, p(x), we use lubrication theory [25], consistent with our assumption of small slopes, |dw/dx| 1. Using standard methods, the pressure may be expressed [30] as…”

mentioning

confidence: 99%

Passive Control of Viscous Flow via Elastic Snap-Through

2017

View full text Add to dashboard Cite

We demonstrate the passive control of viscous flow in a channel by using an elastic arch embedded in the flow. Depending on the fluid flux, the arch may 'snap' between two states -constricting and unconstricting -that differ in hydraulic conductivity by up to an order of magnitude. We use a combination of experiments at a macroscopic scale and theory to study the constricting and unconstricting states, and determine the critical flux required to transition between them. We show that such a device may be precisely tuned for use in a range of applications, and in particular has potential as a passive microfluidic fuse to prevent excessive fluxes in rigid-walled channels.

show abstract

Advanced Transport Phenomena

Cited by 932 publications

References 0 publications

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Hydrodynamic mechanisms of cell and particle trapping in microfluidics

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Passive Control of Viscous Flow via Elastic Snap-Through

Contact Info

Product

Resources

About