Advanced synthetic polymer biomaterials derived from organic sources

Ivanova, Elena P.; Bazaka, Kateryna; Crawford, Russell J.

doi:10.1533/9781782422662.71

Cited by 15 publications

(8 citation statements)

References 103 publications

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“…The best-known are poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and their co-polymers, poly(lactide-co-glycolide) (PLGA) and poly(caprolactone) (PCL) [241]. Poly(Nisopropyl acrylamide) (PNIPAM) and poly(ethylene oxide) (PEO), which are also widely used in the biomedical field, are considered biocompatible, but not biodegradable [242][243][244].…”

Section: Biocompatible Synthetic Polymer-based Particlesmentioning

confidence: 99%

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Albert

Beladjine

Tsapis

et al. 2019

Journal of Controlled Release

318

243

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Section: Biocompatible Synthetic Polymer-based Particlesmentioning

confidence: 99%

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Albert

Beladjine

Tsapis

et al. 2019

Journal of Controlled Release

318

243

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“…Polymers are macromolecules that result from the repetition of smaller molecules, the monomers [ 3 ]. The nature of the monomers and the specific bonds generated between them, and their spatial rearrangement, determine the properties of the built polymer [ 4 ]. The process through which a polymer is formed is named polymerization and can be described as a chemical reaction in which the combination of one or more monomers occurs [ 3 ].…”

Section: Polymers Natural/syntheticmentioning

confidence: 99%

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

2021

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In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

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“…Moreover, PEGylation of nanosystems is an approach commonly adopted to increase their water solubility, biocompatibility and circulation time in the bloodstream (by the reduction in opsonization). The use of PEG has also been extensively explored as a linker between targeting moieties and NPs in order to expose the ligand on the NP surface, to coat the NP surface or for both of these purposes at the same time [64].…”

Section: Polymeric Nanosystemsmentioning

confidence: 99%

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

et al. 2020

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Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed to date is the presence of the CNS barriers that restrict the access to the brain. However, adequate brain biodistribution and neuronal cells specific accumulation in the targeted site also represent major hurdles to the attainment of a successful CNS treatment. Over the last few years, nanotechnology has taken a step forward towards the development of therapeutics in neurologic diseases and different approaches have been developed to surpass these obstacles. The versatility of the designed nanocarriers in terms of physical and chemical properties, and the possibility to functionalize them with specific moieties, have resulted in improved neurotargeted delivery profiles. With the concomitant progress in biology research, many of these strategies have been inspired by nature and have taken advantage of physiological processes to achieve brain delivery. Here, the different nanosystems and targeting moieties used to achieve a neuronal delivery reported in the open literature are comprehensively reviewed and critically discussed, with emphasis on the most recent bioinspired advances in the field. Finally, we express our view on the paramount challenges in targeted neuronal delivery that need to be overcome for these promising therapeutics to move from the bench to the bedside.

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Advanced synthetic polymer biomaterials derived from organic sources

Cited by 15 publications

References 103 publications

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

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