Superconducting Quantum Interference Device (SQUID)‐based instruments have proven to be the most sensitive measurement techniques for not only magnetization measurements but also for a number of other electrical measurements. Their device noise (well below 1 mK), flat frequency and phase response that extends from DC to above 10 GHz, and low drift permit electromagnetic measurements at levels far superior to conventional techniques. SQUID instruments consist of a SQUID amplifier or sensor and a detection circuit that transforms the signal of interest into a magnetic flux that is detected by the SQUID sensor. Associated control electronics transform this signal into a room temperature voltage that is available for additional signal processing if needed. The SQUID amplifier and the detection coils are superconducting devices that are kept at cryogenic temperatures. Various types of SQUID sensors and materials (low‐temperature and high‐temperature superconductors) are discussed along with a wide variety of applications, including laboratory, geophysical, nondestructive test and evaluation along with specific examples of medical applications.