Advanced stent coating for drug delivery and in vivo biocompatibility

Liu, Yi; Wang, Wuchen; Acharya, Gayathri; Shim, Yoon‐Bo; Choe, Eun Sang; Lee, Chi H.

doi:10.1007/s11051-013-1962-1

Cited by 17 publications

(15 citation statements)

References 48 publications

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“…Designing another DES coated using multiple techniques, Liu et al deposited N -nitrosomelatonin (NOMela)-loaded PLGA nanoparticles using EPD onto SS 316L stents, then used dip coating to create a diffusion barrier of collagen [ 134 ]. This work studied the release profiles of a model hydrophobic and hydrophilic drug after immersing the stent in PBS (pH 7.4) with and without 5% ( v / v ) Tween 80, respectively.…”

Section: Des Coating Techniquesmentioning

confidence: 99%

“…This work studied the release profiles of a model hydrophobic and hydrophilic drug after immersing the stent in PBS (pH 7.4) with and without 5% ( v / v ) Tween 80, respectively. The samples, including a top collagen layer, showed a burst release of 50–70% in 24 h, with another 20% of the encapsulated drug released between day two and day 14 [ 134 ]. Overall, the integration of an electrical stimulus to aid in stent coating presents itself as an exciting development.…”

Section: Des Coating Techniquesmentioning

confidence: 99%

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Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Rykowska

Nowak

Nowak³

2020

Molecules

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Controlled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. Heart diseases are particularly important in this aspect. One such disease is an obstructive arterial disease affecting millions of people around the world. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. Modern technology is continually striving to improve the results of previous generations of stents and balloon catheters by refining their design, structure, and constituent materials. These advances result in the development of both successive models of drug-eluting stents (DES) and drug-eluting balloons (DEB). This paper presents milestones in the development of DES and DEB, which are a significant option in the treatment of coronary artery diseases. This report reviews the works related to achievements in construction designs and materials, as well as preparation technologies, of DES and DEB. Special attention was paid to the polymeric biodegradable materials used in the production of the above-mentioned devices. Information was also collected on the various methods of producing drug release coatings and their effectiveness in releasing the active substance.

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Section: Des Coating Techniquesmentioning

confidence: 99%

Section: Des Coating Techniquesmentioning

confidence: 99%

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Rykowska

Nowak

Nowak³

2020

Molecules

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“…From the view of synthetic procedure, although it only consists of three basic steps: immersion, dwell, and withdrawal [46], lots of experimental parameters severely influence the layer thickness and final characteristics of polymer coating such as polymer concentration, solvent properties, viscosity, dwell time, the number of dipping-withdrawal cycles, and immersion/withdrawn speed. Therefore, the latitude of spatial control and the switch of coating materials are hard to be realized [40,46].…”

Section: Dip Techniquementioning

confidence: 99%

“…Therefore, the latitude of spatial control and the switch of coating materials are hard to be realized [40,46]. Undoubtedly, finding the optimal condition is very important for the construction of polymer-coated stents with controllable morphology and structure through dip coating technique.…”

Section: Dip Techniquementioning

confidence: 99%

“…Undoubtedly, finding the optimal condition is very important for the construction of polymer-coated stents with controllable morphology and structure through dip coating technique. Moreover, it has been proved that the loading amount of polymer coating through dip coating method is usually less than that by electrospinning technique, especially for drug loading on stent surface [46].…”

Section: Dip Techniquementioning

confidence: 99%

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The Surface Modification Methods for Constructing Polymer-Coated Stents

Fan

Yang

2018

International Journal of Polymer Science

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Implanting a metal stent plays a key role in treating cardiovascular diseases. However, the high corrosion rate of metal-based devices severely limits their practical applications. Therefore, how to control the corrosion rate is vital to take full advantages of metal-based materials in the treatment of cardiovascular diseases. This review details various methods to design and construct polymer-coated stents. The techniques are described and discussed including plasma deposition, electrospinning, dip coating, layer-by-layer self-assembly, and direct-write inkjet. Key point is provided to highlight current methods and recent advances in hindering corrosion rate and improving biocompatibility of stents, which greatly drives the rising of some promising techniques involved in the ongoing challenges and potential new trends of polymer-coated stents.

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