Advanced stage of chronic kidney disease is risk of poor treatment outcome for smear-positive pulmonary tuberculosis

Microorganisms isolated at admission and treatment outcome in sputum smear-positive pulmonary tuberculosis

“…This study is a retrospective cohort analysis conducted on the population of our previous study at National Hospital Organization Chiba-East Hospital (CEH) in Chiba, Japan [1]. We analyzed the frequency of isolated microorganisms other than Mycobacterium tuberculosis (M. tuberculosis) and oral flora, and 180-day postadmission mortality rates.…”

“…We analyzed the frequency of isolated microorganisms other than Mycobacterium tuberculosis (M. tuberculosis) and oral flora, and 180-day postadmission mortality rates. We also analyzed the risk of isolation of microorganisms associated with underlying conditions, as was analyzed in the former study [1].…”

“…The pathogenesis of the isolation of microorganisms possibly depends upon the host immune condition. We previously showed that some underlying conditions affected TB treatment outcome [1]. In consideration of the comorbidities of the patients with microorganisms, poor PS, respiratory failure, and aging were associated with poor treatment outcomes and possibly confound with the isolation of organisms.…”

“…Aged patients have some underlying conditions, which could affect the treatment outcome [1]. Diabetes mellitus, chronic renal failure, steroid therapy for underlying diseases, etc., were thought to be a kind of immunosuppressive conditions and risk factors for developing active TB from latent tuberculosis infection [2].…”

Infectious Complications of Chronic Kidney Disease in the Developing World

“…Advanced CKD may have a poorer response to anti-TB therapy. 27 There is a significant lack of data regarding TB in children with CKD. From recent personal experience at our center, 3 children out of 45 on chronic dialysis have been diagnosed and treated for TB in the past 2 years.…”