Advanced squamous cell carcinoma of lower gingivobuccal complex: Patterns of spread and failure

Pathak, Kumar Alok; Gupta, Samir; Talole, Sanjay; Khanna, Vishal; Chaturvedi, Pankaj; Deshpande, Mandar; Pai, Prathamesh; Chaukar, Devendra; D’Cruz, Anil

doi:10.1002/hed.20195

Cited by 89 publications

(82 citation statements)

References 30 publications

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“…It is known to have better prognosis than its upper counterpart even in advanced case. [21] In Davangere, people use Gutkha which is placed in the buccal vestibule region. The toxins from the tobacco is absorbed after dilution with saliva and swallowed or spat.…”

Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinoma: A 5 years institutional study

Nayak¹,

Donoghue²,

Selvamani³

2015

JMRPS

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Background: Oral squamous cell carcinoma (OSCC) is a major contributor to disability and death caused by malignant tumors. While of global relevance, variations in social, cultural, and geographic factors affect tumor behavior and response to treatment. In this study, we undertake a 5 years institutional review and analysis of OSCC cases in the south Indian setting. Results: The total number of the patients included 65 males (44.8%) and 80 females (55.2%) whose age ranged from 23 to 80 years (mean ± standard deviation; 52.86 ± 13.18 years). An incidence was highest in 40-45 and 60-65 age group. Buccal mucosa 44 (30.4%) was the most common site, followed by tongue 27 (18.6%). Most lesions (58%) were well differentiated. Patients with poorly differentiated lesions had a comparatively lower mean age than their counterparts with other histological varieties, and this was statistically significant (P < 0.05). Conclusion:The pattern of OSCC differs from that of previous studies in relation to incidence and age correlation with the grade of carcinoma. Since the majority of the lesions were well differentiated, there is a need for intensive oral health awareness to encourage early presentation, to cancer center, as this will further enhance prognosis.

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Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinoma: A 5 years institutional study

Nayak¹,

Donoghue²,

Selvamani³

2015

JMRPS

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“…Spread to lymph nodes in posterior triangle in the absence of metastasis at other levels is rare. [5][6][7] Skip metastasis from gingivobuccal complex carcinomas are rare. Distant metastasis at the time of initial diagnosis is exceedingly rare and occurs to lung and bones.…”

Section: Mode Of Spreadmentioning

confidence: 99%

Management of Gingivobuccal Complex Cancer

Misra

Chaturvedi

Misra

2008

annals

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INTRODUCTION Squamous cell carcinoma of the oral cavity ranks as the 12th most common cancer in the world and the 8th most frequent in males. It accounts for up to one-third of all tobacco-related cancers in India. Cancer of the gingivobuccal complex is especially common in Indians due to their tobacco habits. This review focuses on the management of lower gingivobuccal complex cancers. PATIENTS AND METHODS References for this review were identified by search of Medline and other bibliographic information available in the PubMed database. The search terms carcinoma oral cavity, and cancer oral cavity, buccal mucosa, gingiva, gingivobuccal complex, and alveolus cancer/carcinoma were used. References from relevant articles and abstracts from international conferences were also included. Only articles published in the English language were used. RESULTS Treatment of gingivobuccal complex cancer is primarily surgical. Radical neck dissection, or its modification, is the standard treatment for the node-positive neck. Supraomohyoid neck dissection is the accepted treatment for the node-negative neck. Radiotherapy is usually not the preferred modality of treatment for early gingivobuccal complex cancer. It is used either as postoperative adjuvant treatment or as definitive treatment for advanced cancer with or witihout chemotherapy. Chemotherapy has been used as neo-adjuvant, adjuvant or palliative treatment. Advanced cancers are common and continue to pose a challenge to the multidisciplinary team. CONCLUSIONS Gingivobuccal complex cancer remains a major public health problem despite being highly preventable and easily detectable. Advanced cancers constitute a major proportion of patients presenting for treatment. These patients are difficult to treat and have a poor outcome.

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“…Furthermore, even for those persons who are cured, morbidity remains high due to loss of tissues that are critical for esthetics and function (2). Another significant concern for persons diagnosed with oral SCC is the potential for tumor recurrence or the development of a second primary cancer (3)(4)(5). Clearly, prevention or early detection of precancerous oral lesions combined with strategies for local intervention to prevent progression to overt oral SCC could dramatically improve clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

et al. 2007

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Purpose-The purpose of these studies was to formulate mucoadhesive gels containing freeze dried black raspberries (FBR) and to determine optimum parameters for a subset of FBR bioactive compounds including anthocyanin stability, absorption and penetration in-vitro and in-vivo.Materials and Methods-Berry gels were prepared having FBR at 5% and 10% w/w and final pHs ranging from 3.5 to 7.5. A HPLC assay was developed to quantify and determine the stability of the anthocyanins in the gels. A single time-point study was performed to determine anthocyanin uptake when the gels were applied to oral mucosa. Penetration of anthocyanins into human oral tissue explants was determined as a function of gel pH and FBR content. A HPLC-mass spectroscopy assay was utilized to quantify the anthocyanin levels in human oral tissue explants, saliva, and blood.Results-The stability of anthocyanins in the gel was directly related to gel pH and storage temperature. Maximum stability of anthocyanins was found at lower pH (pH 3.5) and storage temperature (4°C). Anthocyanins contained in mucoadhesive berry gel formulations were readily absorbed into human oral mucosa tissue as evidenced by detectable blood levels within 5 min after gel application. There was a trend for greater penetration of anthocyanins into tissue explants for berry gels with a final pH of 6.5 versus pH 3.5.Conclusions-Formulation and characterization of a novel gel formulation for local delivery of chemopreventive compounds to human oral mucosal tissues has been described. The results show anthocyanin stability was dependent upon gel pH and storage temperature and also demonstrate that the gel composition is well-suited for absorption and penetration into the target oral mucosal tissue site.

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Advanced squamous cell carcinoma of lower gingivobuccal complex: Patterns of spread and failure

Abstract: Gingivobuccal cancers usually fail locoregionally. Soft tissue infiltration and extracapsular spread of nodal disease influence disease-free survival.

Cited by 89 publications

References 30 publications

Oral squamous cell carcinoma: A 5 years institutional study

Oral squamous cell carcinoma: A 5 years institutional study

Management of Gingivobuccal Complex Cancer

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

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