Advanced Squamous Cell Carcinoma of the Larynx

Lindeløv, B.; Hansen, Hanne Sand

doi:10.3109/02841869009090039

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…An emergency laryngectomy has been reported to decrease the risk of peristomal recurrences and thus improve disease-free intervals [15,18,28]. Consequently, an important issue to clarify is which patients with advanced laryngeal cancer benefit the most from an emergency laryngectomy versus tracheotomy when presenting to a clinician in acute respiratory distress.…”

Section: Introductionmentioning

confidence: 97%

The impact of preoperative tracheotomy on T3 transglottic carcinomas of the larynx

Carrillo

Frías-Mendivil

López-Graniel

et al. 1999

European Archives of Oto-Rhino-Laryngology

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To evaluate the impact of the practice of a preoperative tracheotomy and different prognostic factors reported in the literature in patients with transglottic carcinoma of the larynx, a retrospective study was performed in the Instituto Nacional de Cancerologia, Mexico City. In all, 90 cases with T3 transglottic squamous cell carcinoma requiring a total laryngectomy as primary treatment were studied. Prognostic factors such as the Karnofsky index, tumor differentiation, surgical margins and preoperative tracheotomy were analyzed by a Cox's proportional hazards model. The Kaplan-Meier method and log rank test were used to evaluate the disease-free intervals and survival curves. Thirty-two patients had preoperative tracheotomies, while 58 did not. Eighty percent of the patients in the non-preoperative tracheotomy group were alive after 5 years versus 20% of those with preoperative tracheotomies (P < 0.001). Although possibly controversial, our findings indicate that a pretreatment tracheotomy should be avoided in T3 transglottic obstructive lesions. In patients with these lesions and a subglottic extension < or = 3 cm we recommend an emergency total laryngectomy when possible to increase survival and decrease surgical morbidity.

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Section: Introductionmentioning

confidence: 97%

The impact of preoperative tracheotomy on T3 transglottic carcinomas of the larynx

Carrillo

Frías-Mendivil

López-Graniel

et al. 1999

European Archives of Oto-Rhino-Laryngology

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“…however, occur as the cancer spreads and are estimatcd to be present in approximately 5% of T2 tumors, 20%1 of T3, and 30"A of T4 tumors (205). World wide, there are distinct differences in treatment approaches for glottic cancer.…”

Section: Larynx -Glottismentioning

confidence: 99%

Head and Neck Cancer

Möller

1996

Acta Oncologica

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This synthesis of the literature on radiotherapy for head and neck cancer is based on 424 scientific articles, including 3 meta-analyses, 38 randomized studies, 45 prospective studies, and 246 retrospective studies. These studies involve 79174 patients. The literature review shows that radiotherapy, either alone or in combination with surgery, plays an essential role in treating head and neck cancers. When tumors are localized, many tumor patients can be cured by radiotherapy alone and thereby maintain full organ function (1, 2). Current technical advancements in radiotherapy offer the potential for better local tumor control with lower morbidity (3). This, however, will require more sophisticated dose planning resources. To further improve treatment results for advanced tumors, other fractionation schedules, mainly hyperfractionation, should be introduced (5). This mainly increases the demands on staff resources for radiotherapy. The combination of radiotherapy and chemotherapy should be subjected to further controlled studies involving a sufficiently large number of patients (4, 5). Interstitial treatment (in the hands of experienced radiotherapists) yields good results for selected cancers. The method should be more generally accessible in Sweden. Intraoperative radiotherapy should be targeted for further study and development.

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Advanced Squamous Cell Carcinoma of the Larynx

Cited by 2 publications

References 7 publications

The impact of preoperative tracheotomy on T3 transglottic carcinomas of the larynx

The impact of preoperative tracheotomy on T3 transglottic carcinomas of the larynx

Head and Neck Cancer

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