Advanced Squamous Cell Carcinoma of the Skin

Vazquez, Vinícius de Lima; Serrano, Sergio; Capuzzo, Renato de Castro

doi:10.5772/25546

Cited by 1 publication

(6 citation statements)

References 72 publications

(74 reference statements)

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“…46 The ITEM prognostic system utilizes four factors that are determined after the surgical excision of SCC: Immunosuppression; Treatment; Extranodal spread; and Margin. 40 This study denounced prior findings that human epidermal receptor (HER) and E-cadherin positivity may be linked with prognosis. In the 250 patients studied by the developers of this classification scheme, 5-year mortality rates in patients with high-, moderate-and low-risk ITEM scores were 56, 24, and 6%, respectively.…”

Section: Novel Classification Schemesmentioning

confidence: 65%

“…One study found that increased expression of the podoplanin tumor marker correlates with lower survival rates. 40 This study denounced prior findings that human epidermal receptor (HER) and E-cadherin positivity may be linked with prognosis.…”

Section: Novel Classification Schemesmentioning

confidence: 65%

“…40 Broder originally proposed this grading system in 1932; it divides SCC into four categories based on histological grade. The Broder grading system, mitotic index, and lymphocytic infiltrate are commonly utilized but not proven to affect prognosis.…”

Section: Novel Classification Schemesmentioning

confidence: 99%

“…50 Tumors of >2.0 cm in diameterstage T2 or highershould be removed with margins of ≥6.0 mm. 40 Mohs micrographic surgery (MMS) is reported to achieve better cure rates than standard excision. Microscopic metastases may be found with high-risk primary cutaneous SCC.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

“…The Broder grading system, mitotic index, and lymphocytic infiltrate are commonly utilized but not proven to affect prognosis. 40 Broder originally proposed this grading system in 1932; it divides SCC into four categories based on histological grade. Grade I is composed of well-differentiated tumors, in which 75-100% of squamous cells are differentiated.…”

Section: Novel Classification Schemesmentioning

confidence: 99%

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Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends

2014

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Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). We describe the salient features of cutaneous SCC. We also review novel classification schemes proposed during the last decade which attempt to stratify SCC lesions based on prognosis. Biopsy leads to definitive diagnosis. Treatment includes surgical excision; Mohs micrographic surgery produces excellent cure rates and spares the maximal amount of tissue. Other modalities include electrodessication and curettage, cryosurgery, radiotherapy, topical medications, photodynamic therapy, and systemic therapy. Management and follow-up depend on the risk stratification of individual lesions.

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Section: Novel Classification Schemesmentioning

confidence: 65%

Section: Novel Classification Schemesmentioning

confidence: 65%

Section: Novel Classification Schemesmentioning

confidence: 99%

Section: Treatment Modalitiesmentioning

confidence: 99%

Section: Novel Classification Schemesmentioning

confidence: 99%

See 3 more Smart Citations