More than 23,000 structures, located in over 30 countries, have been so far protected by passive anti-seismic (AS) systems, mainly by the seismic isolation (SI) and energy dissipation (ED) ones. The use of such systems is going on increasing everywhere, although its extent is strongly influenced by earthquake lessons and the features of the design rules used. As to the latter, SI is considered as an additional safety measure (with consequent significant additional construction costs) in some countries (Japan, USA, etc.), while, in others (including Italy), the codes allow to partly take into account the reduction of the seismic forces acting on the superstructure that is induced by SI. Applications of the AS systems have been made to both new and existing civil and industrial structures of all kinds. The latter include some high risk (HR) plants (nuclear reactors and chemical installations). The applications in a civil context already include not only strategic and A. Martelli (*) ENEA,