Advanced SA/PVA-based hydrogel matrices with prolonged release of Aloe vera as promising wound dressings

Bialik-Wąs, Katarzyna; Pluta, Klaudia; Malina, Dagmara; Barczewski, Mateusz; Malarz, Katarzyna; Mrozek-Wilczkiewicz, Anna

doi:10.1016/j.msec.2020.111667

Cited by 65 publications

(66 citation statements)

References 59 publications

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“…The impact of the microstructure on the mechanical properties of sodium alginate/PVA hydrogels matrices loaded with Aloe vera was studied by Bialik-Wąs et al . ( 39 ). The combination of sodium alginate with PVA improved the flexibility of brittle alginate dressings.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, there has been a growing interest in the design of PVA matrices that could not only effectively deliver antiinflammatory agents ( 45 ), antimicrobials ( 8 , 46 ) or plant extracts ( 39 ) to the wound bed, but also control their release from the dressing material to this application site. Since the solubility of RSV in PG was 80 times higher than that determined in water or in buffers; PG was chosen to study its release from prepared cryogels.…”

Section: Resultsmentioning

confidence: 99%

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Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings

et al. 2021

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Hydrogel wound dressings are highly effective in the therapy of wounds. Yet, most of them do not contain any active ingredient that could accelerate healing. The aim of this study was to prepare hydrophilic active dressings loaded with an anti-inflammatory compound - trans-resveratrol (RSV) of hydrophobic properties. A special attention was paid to select such a technological strategy that could both reduce the risk of irritation at the application site and ensure the homogeneity of the final hydrogel. RSV dissolved in Labrasol was combined with an aqueous sol of poly(vinyl) alcohol (PVA), containing propylene glycol (PG) as a plasticizer. This sol was transformed into a gel under six consecutive cycles of freezing (-80 °C) and thawing (RT). White, uniform and elastic membranes were successfully produced. Their critical features, namely microstructure, mechanical properties, water uptake and RSV release were studied using SEM, DSC, MRI, texture analyser and Franz-diffusion cells. The cryogels made of 8 % of PVA showed optimal tensile strength (0.22 MPa) and elasticity (0.082 MPa). The application of MRI enabled to elucidate mass transport related phenomena in this complex system at the molecular (detection of PG, confinement effects related to pore size) as well as at the macro level (swelling). The controlled release of RSV from membranes was observed for 48 h with mean dissolution time of 18 h and dissolution efficiency of 35 %. All in all, these cryogels could be considered as a promising new active wound dressings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings

et al. 2021

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“…In the wave number range of 3000-3500 cm −1 in all the spectra, a wide range of bands is visible, corresponding to stretching vibrations of -OH bonds present in PVA, SA and the Echinacea purpurea extract (active substances including echinacoside and also Hbonded alcohols and phenols) [28,[50][51][52]. In the case of the hydrogels obtained by chemical crosslinking, we notice an intense band originating from stretching vibrations of the C-H groups (3000-2850 cm −1 ), stretching vibrations of the -CH 3 groups (2922 cm −1 ), and vibrations of C-H and O-H bendings at 1350-1330 cm −1 [28,29].…”

Section: Ft-ir Analysismentioning

confidence: 99%

“…Next, appropriate amounts of these solutions as well as a constant amount of glycerine (3.5%) (using method I-ionic crosslinking) were mixed. In the case of method II-chemical crosslinking-constant amounts of poly(ethylene glycol) diacrylate (7.75%) were added [49,50]. Detailed descriptions of the mixture compositions used for hydrogel preparation are shown in Table 1.…”

Section: Preparation Of Sa/pva/echinacea Purpurea Hydrogelsmentioning

confidence: 99%

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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“…y el árbol de aloe (Aloe arborescens Mill.). Los geles de las especies de éste último y Aloe ferox, mostraron actividad farmacológica en la cicatrización de heridas (Bialik-Wąs et al, 2021;Guillén et al, 2013;Solek et al, 2018) El género aloe, es una hierba suculenta de 80 -100 cm de altura que madura en 4 -6 años y sobrevive durante casi 50 años en condiciones favorables (Sahu et al, 2013). La planta puede sobrevivir a una temperatura de 40 °C y por debajo de la temperatura de congelación, dependiendo de la salud de la raíz (Baruah et al, 2016).…”

Section: El Aloe Vera (Aloe Barbadensis Miller)unclassified

Conservación de las propiedades nutraceúticas del Aloe Vera (Aloe Barbadensis Miller), mediante técnicas de secado

Antury

Rojas

Bermeo

2021

Ingeniería y Región

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Se realizó el análisis de las aplicaciones y técnicas de secado para la obtención de polvo de aloe vera, usado en la elaboración de productos alimentarios, farmacéuticos y cosméticos. Para lo anterior, se tuvo en cuenta las técnicas existentes y aquellas que permiten la mayor conservación de sus propiedades nutracéuticas y funcionales para la elaboración de éstos productos, garantizando inocuidad y seguridad para el consumidor. Se realizó una descripción respecto al funcionamiento y algunas pautas de los equipos, seleccionando el método de deshidratación más adecuado para producir un producto de alta calidad. Para el desarrollo de éste, se consultaron las principales bases de datos como Science Direct, EBSCO, Springer Journals, Scopus, ProQuest Central, Redalyc, Wiley Online Library entre otras. Se determinó, que las técnicas que permite la mayor conservación de las propiedades del aloe vera fueron: secado por aspersión, liofilización y ventana refractante, debido a las bajas temperaturas usadas, la cual evita la degradación de sus componentes (dada a la alta sensibilidad del gel a temperaturas superiores a 50°C). En cuanto a costos y tiempo de operación, el secado por aspersión es la tecnología que presenta mayores beneficios.

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Advanced SA/PVA-based hydrogel matrices with prolonged release of Aloe vera as promising wound dressings

Cited by 65 publications

References 59 publications

Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings

Poly(Vinyl Alcohol) Cryogel Membranes Loaded with Resveratrol as Potential Active Wound Dressings

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Conservación de las propiedades nutraceúticas del Aloe Vera (Aloe Barbadensis Miller), mediante técnicas de secado

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