Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens

Duport, Catherine; Alpha-Bazin, Béatrice; Armengaud, Jean

doi:10.3390/toxins11100576

Cited by 14 publications

(10 citation statements)

References 127 publications

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“…Interestingly, the functions of these proteins inside and outside the cells are not the same, and some of them are involved in cell defence or virulence [19]. Exotoxins have, thus, different modes of action giving bacteria a wide range of virulence mechanisms [20].…”

Section: T6ss T3ss T2ssmentioning

confidence: 99%

Exoproteomics for Better Understanding Pseudomonas aeruginosa Virulence

Sauvage

Hardouin

2020

Toxins

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Pseudomonas aeruginosa is the most common human opportunistic pathogen associated with nosocomial diseases. In 2017, the World Health Organization has classified P. aeruginosa as a critical agent threatening human health, and for which the development of new treatments is urgently necessary. One interesting avenue is to target virulence factors to understand P. aeruginosa pathogenicity. Thus, characterising exoproteins of P. aeruginosa is a hot research topic and proteomics is a powerful approach that provides important information to gain insights on bacterial virulence. The aim of this review is to focus on the contribution of proteomics to the studies of P. aeruginosa exoproteins, highlighting its relevance in the discovery of virulence factors, post-translational modifications on exoproteins and host-pathogen relationships.

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Section: T6ss T3ss T2ssmentioning

confidence: 99%

Exoproteomics for Better Understanding Pseudomonas aeruginosa Virulence

Sauvage

Hardouin

2020

Toxins

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“…Exotoxins are a collection of protein that in order to alter the physiology of the host cell, are secreted by the bacterium, enter host cells and catalyse the covalent modification of a host cell portion (Duport et al, 2019). Exotoxins are produced in both Gram‐negative and Gram‐positive bacteria.…”

Section: Bacterial Interaction Through Virulence Factorsmentioning

confidence: 99%

Pathogenic bacterial toxins and virulence influences in cultivable fish

Sarkar

Issac

Raju

et al. 2021

Aquaculture Research

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Bacterial virulence factors play a major role in infection, which provides devastating effect on the aquaculture industry. Bacterial toxins are the major virulence factors that influence the roles of host cells and take control of living organisms’ vital processes to facilitate microbial infection. Various other bacterial virulent components such as adhesins, capsular polysaccharides, lipopolysaccharides, bacterial flagellum, pili and microbial siderophore provide a diverse effect in the microbial pathogenesis and express a variety of pathogenic molecules including aebABCEG, HutA, cpsD and pPHDD1. Bacterial protein secretion system secretes enzymes and toxins from bacterial cytoplasm to the host membrane targeting the immune cells and promoting biofilm formation. However, as they enter, the host body expresses various immune molecules that interact to utilize the pathogen recognition receptors. Toxins are powerful molecules formed by a broad range of bacterial pathogens attacking host cells and playing key roles in the dialogue between host and pathogen. They are important virulence factors that are often enough to decide the outcome of the infection. Hence, a detailed view on the virulence molecules majorly exotoxins from various bacterial pathogenic strains that are necessary to understand the pathogenesis. This review focuses on bacterial toxins and various other virulence factors, which influence the pathogenesis in fish.

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“…Bacterial toxins with promising anticancer activity include botulinum neurotoxin type A, diphtheria toxin, exotoxin A, and listeriolysin O [ 88 ]. Although most of these toxins have been extensively studied for many years, advances in proteomics have provided new insights into their structure and function [ 89 ].…”

Section: Bacterial Toxins For Cancer Therapymentioning

confidence: 99%

“…One of the most important contributions of next-generation proteomics is the detection of post-translational modifications of proteins (PTMs) that affect both protein homeostasis and the cellular processes in which they participate. Bacteria contain many different types of PTMs, such as oxidation, acetylation, phosphorylation, and S-thiolation that can potentially affect toxins and modulate their function [ 89 ]. Furthermore, post-translational modifications can occur during the production and storage of most therapeutic proteins derived from bacterial toxins.…”

Section: Bacterial Toxins For Cancer Therapymentioning

confidence: 99%

Fighting Cancer with Bacteria and Their Toxins

Trivanović

Pavelić

Peršurić

2021

IJMS

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Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents.

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Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens

Cited by 14 publications

References 127 publications

Exoproteomics for Better Understanding Pseudomonas aeruginosa Virulence

Exoproteomics for Better Understanding Pseudomonas aeruginosa Virulence

Pathogenic bacterial toxins and virulence influences in cultivable fish

Fighting Cancer with Bacteria and Their Toxins

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